Intravesical Lactobacillus for Urinary Symptoms Among People with NLUTD Who Use Indwelling Catheters

Description

The objectives of the proposed research among this population are: 1) to define clinically meaningful change (i.e. differentiating states of health and illness) with respect to urinary symptoms, urine inflammation, cultivable bacteria, and the urine ecosystem; and 2) to determine the optimal intravesical Lactobacillus RhamnosusGG (LGG®) dose to be used to reduce urinary symptoms in a future clinical trial.

Conditions

Neurogenic Bladder

Study Overview

Study Details

Study overview

The objectives of the proposed research among this population are: 1) to define clinically meaningful change (i.e. differentiating states of health and illness) with respect to urinary symptoms, urine inflammation, cultivable bacteria, and the urine ecosystem; and 2) to determine the optimal intravesical Lactobacillus RhamnosusGG (LGG®) dose to be used to reduce urinary symptoms in a future clinical trial.

Intravesical Lactobacillus for Urinary Symptoms Among People with NLUTD Who Use Indwelling Catheters

Intravesical Lactobacillus for Urinary Symptoms Among People with NLUTD Who Use Indwelling Catheters

Condition
Neurogenic Bladder
Intervention / Treatment

-

Contacts and Locations

Washington

MedStar National Rehabilitation Hospital, Washington, District of Columbia, United States, 20010

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Neurogenic bladder for at least 6 months;
  • * Utilizing indwelling catheterization for bladder management;
  • * Women must be premenopausal and not currently menstruating;
  • * Community dwelling
  • * physical disability
  • * Use of prophylactic antibiotics;
  • * Instillation of intravesical antimicrobials to prevent UTI;
  • * Psychologic or psychiatric conditions influencing the ability to follow instructions;
  • * Use of oral or IV antibiotics within the past 2 weeks;
  • * Sexual activity within the previous 72 hours;
  • * Participation in another study with which results could be confounded.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Medstar Health Research Institute,

Suzanne Groah, MD, MSPH, PRINCIPAL_INVESTIGATOR, MedStar National Rehabilitation Hospital

Study Record Dates

2025-09