The goal of this study is to understand the role of brain glucose transport in individuals with obesity and the association with cerebral hypometabolism and these individuals' response to plasma glucose elevations. The main premise is that obesity leads to reduced brain glucose transport and that we can measure this reduction with magnetic resonance spectroscopy (MRS). The secondary premises are that this reduction is driven by elevated non esterified fatty acids which act to turn on specific signaling pathways that regulate brain GLUT1 levels.
Obesity
The goal of this study is to understand the role of brain glucose transport in individuals with obesity and the association with cerebral hypometabolism and these individuals' response to plasma glucose elevations. The main premise is that obesity leads to reduced brain glucose transport and that we can measure this reduction with magnetic resonance spectroscopy (MRS). The secondary premises are that this reduction is driven by elevated non esterified fatty acids which act to turn on specific signaling pathways that regulate brain GLUT1 levels.
Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism
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Biomedical Research Imaging Center Marsico Hall (UNC), Chapel Hill, North Carolina, United States, 27514
Clinical and Translational Research Center (CTRC) Burnett-Womack Building (UNC), Chapel Hill, North Carolina, United States, 27514
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
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18 Years to 45 Years
ALL
Yes
University of North Carolina, Chapel Hill,
Janice Jin Hwang, MD, MHS, PRINCIPAL_INVESTIGATOR, University of North Carolina, Chapel Hill
2025-06-01