The Genomic Medicine at VA Study

Description

This trial will determine the clinical effectiveness of polygenic risk score testing among patients at high genetic risk for at least one of six diseases (coronary artery disease, atrial fibrillation, type 2 diabetes mellitus, colorectal cancer, breast cancer, or prostate cancer), measured by time-to-diagnosis of prevalent or incident disease over 24 months.

Conditions

Coronary Artery Disease, Atrial Fibrillation, Type 2 Diabetes, Colorectal Cancer, Breast Cancer, Prostate Cancer

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Study Overview

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Study Details

Study overview

This trial will determine the clinical effectiveness of polygenic risk score testing among patients at high genetic risk for at least one of six diseases (coronary artery disease, atrial fibrillation, type 2 diabetes mellitus, colorectal cancer, breast cancer, or prostate cancer), measured by time-to-diagnosis of prevalent or incident disease over 24 months.

Pragmatic Randomized Trial of Polygenic Risk Scoring for Common Diseases in Primary Care

The Genomic Medicine at VA Study

Condition
Coronary Artery Disease
Intervention / Treatment

-

Contacts and Locations

Boston

VA Boston Healthcare System, Boston, Massachusetts, United States, 02130-4817

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 50-70 years at enrollment
  • * No known diagnosis of the following conditions, initially screened by the International Classification of Disease (ICD) codes or other electronic health record (EHR) data using validated methods and then confirmed with potential patient-participants during recruitment: coronary artery disease, atrial fibrillation, type 2 diabetes, colorectal cancer, breast cancer, prostate cancer
  • * Patients will be ineligible if they:
  • * Have a known diagnosis of at least one of the six diseases of interest
  • * Are younger than age 50 or older than age 70
  • * Are pregnant
  • * Are incarcerated or institutionalized

Ages Eligible for Study

50 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Boston VA Research Institute, Inc.,

Jason L. Vassy, MD, MPH, SM, PRINCIPAL_INVESTIGATOR, Harvard Medical School (HMS and HSDM)

Study Record Dates

2025-09-30