RECRUITING

Study of Nicotinamide Riboside Supplementation in Allogeneic Hematopoietic Cell Transplantation

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to find a safe and tolerable way to improve engraftment after transplant. Research studies have shown that adding nicotinamide riboside to donor cells has the potential to increase blood stem cell numbers and potentially decrease the time to engraftment. Also, nicotinamide riboside, TRU NIAGEN (the study drug) is a type of vitamin B supplement that the general public can get without a prescription and is well tolerated.

Official Title

A Pilot Study of Nicotinamide Riboside Supplementation in Allogeneic Hematopoietic Cell Transplantation

Quick Facts

Study Start:2020-05-19
Study Completion:2026-04-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04332341

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * All disease indications for allogeneic hematopoietic cell transplantation except for myelofibrosis.
  2. * Subject must meet program eligibility criteria\* for myeloablative conditioning alloHCT and plan to undergo myeloablative conditioning.
  3. * HLA-identical related donor or unrelated human donor source with bone marrow graft.
  4. * Subjects must provide a written informed consent.
  1. * History of allergy or intolerance to NR precursor compounds, including niacin or nicotinamide
  2. * Pregnant or breastfeeding women are excluded from this study since allogeneic HCT is a strict contraindication.
  3. * Subjects with uncontrolled intercurrent illness or psychiatric illness/social situations that would limit compliance with study requirements.

Contacts and Locations

Study Contact

Ronald Sobecks, MD
CONTACT
1-866-223-8100
TaussigResearch@ccf.org

Principal Investigator

Ronald Sobecks, MD
PRINCIPAL_INVESTIGATOR
Cleveland Clinic, Case Comprehensive Cancer Center

Study Locations (Sites)

Cleveland Clinic, Case Comprehensive Cancer Center
Cleveland, Ohio, 44195
United States

Collaborators and Investigators

Sponsor: Case Comprehensive Cancer Center

  • Ronald Sobecks, MD, PRINCIPAL_INVESTIGATOR, Cleveland Clinic, Case Comprehensive Cancer Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-05-19
Study Completion Date2026-04-01

Study Record Updates

Study Start Date2020-05-19
Study Completion Date2026-04-01

Terms related to this study

Additional Relevant MeSH Terms

  • Allogeneic Hematopoietic Cell Transplantation