ACTIVE_NOT_RECRUITING

Testing the Use of the Usual Chemotherapy Before and After Surgery for Removable Pancreatic Cancer

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Conditions

Pancreatic Adenosquamous CarcinomaResectable Pancreatic AdenocarcinomaPancreatic Cancer

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This phase III trial compares perioperative chemotherapy (given before and after surgery) versus adjuvant chemotherapy (given after surgery) for the treatment of pancreatic cancer that can be removed by surgery (removable/resectable). Chemotherapy drugs, such as fluorouracil, irinotecan, leucovorin, and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving chemotherapy before and after surgery (perioperatively) may work better in treating patients with pancreatic cancer compared to giving chemotherapy after surgery (adjuvantly).

Official Title

A Phase III Trial of Perioperative Versus Adjuvant Chemotherapy for Resectable Pancreatic Cancer

Quick Facts

Study Start:2020-10-13
Study Completion:2030-11-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT04340141

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Pathology: Histologic or cytologic proof of pancreatic adenocarcinoma or adenosquamous carcinoma
  2. * TNM Stage: Tx-4, N0-1, M0 (M0 disease does not include spread to distant lymph nodes and organs)
  3. * Resectable Primary Tumor: Local radiographic reading must be consistent with resectable disease defined as the following on 1) arterial and venous phase contrast-enhanced abdominal/pelvic CT scan or abdominal/pelvic magnetic resonance imaging (MRI) scan and 2) chest CT:
  4. * No involvement or abutment of the celiac artery, common hepatic artery, superior mesenteric artery, or replaced right hepatic artery (if applicable)
  5. * Less than 180 degree interface between tumor and vessel wall of the portal vein or superior mesenteric vein, and patent portal vein/splenic vein confluence
  6. * No evidence of metastatic disease
  7. * Measurable disease or non-measurable disease o Non-measurable disease is defined as cytologic or histologic confirmation of adenocarcinoma of adenosquamous carcinoma by fine needle aspiration or core-biopsy of the pancreas without measurable disease by radiographic imaging
  8. * Confirmation of resectable disease by real-time central imaging review by the Alliance Imaging Core Lab at Imaging and Radiation Oncology Core (IROC) Ohio
  9. * Determined to be appropriate candidate for curative-intent pancreatectomy by surgeon intending to perform the resection
  10. * No prior radiation therapy, chemotherapy, targeted therapy, investigational therapy, or surgery for pancreatic cancer
  11. * Not pregnant and not nursing, because this study involves an agent that has known genotoxic, mutagenic, and teratogenic effects.
  12. * Therefore, for women of childbearing potential only, a negative pregnancy test done =\< 14 days prior to registration is required
  13. * Eastern Cooperative Oncology Group (ECOG) performance status 0-1
  14. * Total Neuropathy Score \< 2
  15. * Absolute neutrophil count (ANC) \>= 1,500/uL
  16. * Platelet count \>= 100,000/uL
  17. * Total bilirubin =\< 1.5 x upper limit of normal (ULN) (If obstructive jaundice is present, then biliary drainage must be initiated and total bilirubin =\< 3.0)
  18. * Creatinine =\< 1.5 x ULN OR calculated (Calc.) creatinine clearance \>= 30 mL/min (Calculated using the Cockcroft-Gault equation)
  19. * No known Gilbert's Syndrome or known homozygosity for UGAT1A1\*28 polymorphism
  20. * No comorbid conditions that would prohibit curative-intent pancreatectomy
  21. * Chronic concomitant treatment with strong inhibitors of CYP3A4 is not allowed on this study. Patients on strong CYP3A4 inhibitors must discontinue the drug prior to registration
  22. * Chronic concomitant treatment with strong inducers of CYP3A4 is not allowed on this study. Patients on strong CYP3A4 inducers must discontinue the drug prior to registration
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Principal Investigator

Cristina R. Ferrone, MD
STUDY_CHAIR
Massachusetts General Hospital

Study Locations (Sites)

University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, 35233
United States
Thomas Hospital
Fairhope, Alabama, 36532
United States
Mobile Infirmary Medical Center
Mobile, Alabama, 36607
United States
University of South Alabama Mitchell Cancer Institute
Mobile, Alabama, 36688
United States
Anchorage Associates in Radiation Medicine
Anchorage, Alaska, 98508
United States
Alaska Breast Care and Surgery LLC
Anchorage, Alaska, 99508
United States
Alaska Oncology and Hematology LLC
Anchorage, Alaska, 99508
United States
Alaska Women's Cancer Care
Anchorage, Alaska, 99508
United States
Anchorage Oncology Centre
Anchorage, Alaska, 99508
United States
Katmai Oncology Group
Anchorage, Alaska, 99508
United States
Providence Alaska Medical Center
Anchorage, Alaska, 99508
United States
Banner University Medical Center - Tucson
Tucson, Arizona, 85719
United States
University of Arizona Cancer Center-North Campus
Tucson, Arizona, 85719
United States
Mercy Hospital Fort Smith
Fort Smith, Arkansas, 72903
United States
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, Arkansas, 72401
United States
University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205
United States
Kaiser Permanente-Anaheim
Anaheim, California, 92806
United States
Kaiser Permanente-Deer Valley Medical Center
Antioch, California, 94531
United States
Sutter Cancer Centers Radiation Oncology Services-Auburn
Auburn, California, 95603
United States
Kaiser Permanente-Bellflower
Bellflower, California, 90706
United States
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California, 94704
United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, California, 91505
United States
Mills-Peninsula Medical Center
Burlingame, California, 94010
United States
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Cameron Park, California, 95682
United States
Community Cancer Institute
Clovis, California, 93611
United States
UC Irvine Health Cancer Center-Newport
Costa Mesa, California, 92627
United States
Kaiser Permanente Dublin
Dublin, California, 94568
United States
Kaiser Permanente-Fremont
Fremont, California, 94538
United States
Kaiser Permanente Fresno Orchard Plaza
Fresno, California, 93720
United States
Kaiser Permanente-Fresno
Fresno, California, 93720
United States
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, California, 92612
United States
Kaiser Permanente-Irvine
Irvine, California, 92618
United States
UC San Diego Moores Cancer Center
La Jolla, California, 92093
United States
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, 90027
United States
Los Angeles General Medical Center
Los Angeles, California, 90033
United States
USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033
United States
Kaiser Permanente West Los Angeles
Los Angeles, California, 90034
United States
Cedars Sinai Medical Center
Los Angeles, California, 90048
United States
Memorial Medical Center
Modesto, California, 95355
United States
Kaiser Permanente-Modesto
Modesto, California, 95356
United States
Palo Alto Medical Foundation-Camino Division
Mountain View, California, 94040
United States
Kaiser Permanente-Oakland
Oakland, California, 94611
United States
Saint Joseph Hospital - Orange
Orange, California, 92868
United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California, 92868
United States
Palo Alto Medical Foundation Health Care
Palo Alto, California, 94301
United States
Stanford Cancer Institute Palo Alto
Palo Alto, California, 94304
United States
Kaiser Permanente-Redwood City
Redwood City, California, 94063
United States
Kaiser Permanente-Richmond
Richmond, California, 94801
United States
Kaiser Permanente-Riverside
Riverside, California, 92505
United States
Kaiser Permanente-Roseville
Roseville, California, 95661
United States
Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville, California, 95661
United States
Sutter Roseville Medical Center
Roseville, California, 95661
United States
Kaiser Permanente Downtown Commons
Sacramento, California, 95814
United States
Sutter Medical Center Sacramento
Sacramento, California, 95816
United States
University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817
United States
Kaiser Permanente-South Sacramento
Sacramento, California, 95823
United States
UC San Diego Medical Center - Hillcrest
San Diego, California, 92103
United States
Kaiser Permanente-San Diego Zion
San Diego, California, 92120
United States
California Pacific Medical Center-Pacific Campus
San Francisco, California, 94115
United States
Kaiser Permanente-San Francisco
San Francisco, California, 94115
United States
UCSF Medical Center-Mission Bay
San Francisco, California, 94158
United States
Kaiser Permanente-Santa Teresa-San Jose
San Jose, California, 95119
United States
Kaiser Permanente San Leandro
San Leandro, California, 94577
United States
Mills Health Center
San Mateo, California, 94401
United States
Kaiser San Rafael-Gallinas
San Rafael, California, 94903
United States
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, 95051
United States
Kaiser Permanente-Santa Rosa
Santa Rosa, California, 95403
United States
Kaiser Permanente-South San Francisco
South San Francisco, California, 94080
United States
Kaiser Permanente-Stockton
Stockton, California, 95210
United States
Palo Alto Medical Foundation-Sunnyvale
Sunnyvale, California, 94086
United States
Kaiser Permanente Medical Center-Vacaville
Vacaville, California, 95688
United States
Kaiser Permanente-Vallejo
Vallejo, California, 94589
United States
Sutter Solano Medical Center/Cancer Center
Vallejo, California, 94589
United States
Kaiser Permanente-Walnut Creek
Walnut Creek, California, 94596
United States
AdventHealth Porter
Denver, Colorado, 80210
United States
Danbury Hospital
Danbury, Connecticut, 06810
United States
Smilow Cancer Hospital-Derby Care Center
Derby, Connecticut, 06418
United States
Smilow Cancer Hospital Care Center-Fairfield
Fairfield, Connecticut, 06824
United States
Smilow Cancer Hospital Care Center at Glastonbury
Glastonbury, Connecticut, 06033
United States
Smilow Cancer Hospital Care Center at Greenwich
Greenwich, Connecticut, 06830
United States
Smilow Cancer Hospital Care Center - Guilford
Guilford, Connecticut, 06437
United States
Hartford Hospital
Hartford, Connecticut, 06102
United States
Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut, 06105
United States
Midstate Medical Center
Meriden, Connecticut, 06451
United States
The Hospital of Central Connecticut
New Britain, Connecticut, 06050
United States
Yale University
New Haven, Connecticut, 06520
United States
Yale-New Haven Hospital North Haven Medical Center
North Haven, Connecticut, 06473
United States
Norwalk Hospital
Norwalk, Connecticut, 06856
United States
Smilow Cancer Hospital-Orange Care Center
Orange, Connecticut, 06477
United States
Smilow Cancer Hospital-Torrington Care Center
Torrington, Connecticut, 06790
United States
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut, 06611
United States
Smilow Cancer Hospital-Waterbury Care Center
Waterbury, Connecticut, 06708
United States
Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut, 06385
United States
MedStar Georgetown University Hospital
Washington D.C., District of Columbia, 20007
United States
MedStar Washington Hospital Center
Washington D.C., District of Columbia, 20010
United States
Sibley Memorial Hospital
Washington D.C., District of Columbia, 20016
United States
AdventHealth Altamonte
Altamonte Springs, Florida, 32701
United States
Mount Sinai Comprehensive Cancer Center at Aventura
Aventura, Florida, 33180
United States
Schulze Family Foundation Cancer Clinic - Bonita Health Center
Bonita Springs, Florida, 34135
United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida, 33146
United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, 33442
United States
Regional Cancer Center-Lee Memorial Health System
Fort Myers, Florida, 33905
United States
UF Health Cancer Institute - Gainesville
Gainesville, Florida, 32610
United States
Jupiter Medical Center
Jupiter, Florida, 33458
United States
Lakeland Regional Health Hollis Cancer Center
Lakeland, Florida, 33805
United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, 33136
United States
UM Sylvester Comprehensive Cancer Center at Kendall
Miami, Florida, 33176
United States
Mount Sinai Medical Center
Miami Beach, Florida, 33140
United States
AdventHealth Orlando
Orlando, Florida, 32803
United States
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation, Florida, 33324
United States
Tampa General Hospital
Tampa, Florida, 33606
United States
Cleveland Clinic-Weston
Weston, Florida, 33331
United States
Phoebe Putney Memorial Hospital
Albany, Georgia, 31701
United States
Augusta University Medical Center
Augusta, Georgia, 30912
United States
Northeast Georgia Medical Center-Gainesville
Gainesville, Georgia, 30501
United States
Queen's Medical Center
Honolulu, Hawaii, 96813
United States
Kaiser Permanente Moanalua Medical Center
Honolulu, Hawaii, 96819
United States
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho, 83706
United States
Saint Luke's Cancer Institute - Boise
Boise, Idaho, 83712
United States
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho, 83605
United States
Kootenai Health - Coeur d'Alene
Coeur d'Alene, Idaho, 83814
United States
Saint Luke's Cancer Institute - Fruitland
Fruitland, Idaho, 83619
United States
Idaho Urologic Institute-Meridian
Meridian, Idaho, 83642
United States
Saint Luke's Cancer Institute - Meridian
Meridian, Idaho, 83642
United States
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho, 83687
United States
Saint Luke's Cancer Institute - Nampa
Nampa, Idaho, 83687
United States
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho, 83854
United States
Saint Luke's Cancer Institute - Twin Falls
Twin Falls, Idaho, 83301
United States
Rush-Copley Medical Center
Aurora, Illinois, 60504
United States
Illinois CancerCare-Bloomington
Bloomington, Illinois, 61704
United States
Illinois CancerCare-Canton
Canton, Illinois, 61520
United States
Memorial Hospital of Carbondale
Carbondale, Illinois, 62902
United States
SIH Cancer Institute
Carterville, Illinois, 62918
United States
Illinois CancerCare-Carthage
Carthage, Illinois, 62321
United States
Centralia Oncology Clinic
Centralia, Illinois, 62801
United States
Northwestern University
Chicago, Illinois, 60611
United States
John H Stroger Jr Hospital of Cook County
Chicago, Illinois, 60612
United States
University of Illinois
Chicago, Illinois, 60612
United States
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637
United States
Carle at The Riverfront
Danville, Illinois, 61832
United States
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, 62526
United States
Decatur Memorial Hospital
Decatur, Illinois, 62526
United States
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois, 60115
United States
Carle Physician Group-Effingham
Effingham, Illinois, 62401
United States
Crossroads Cancer Center
Effingham, Illinois, 62401
United States
Illinois CancerCare-Eureka
Eureka, Illinois, 61530
United States
Illinois CancerCare-Galesburg
Galesburg, Illinois, 61401
United States
Western Illinois Cancer Treatment Center
Galesburg, Illinois, 61401
United States
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, 60134
United States
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois, 61443
United States
Illinois CancerCare-Macomb
Macomb, Illinois, 61455
United States
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois, 61938
United States
Loyola University Medical Center
Maywood, Illinois, 60153
United States
SSM Health Good Samaritan
Mount Vernon, Illinois, 62864
United States
Cancer Care Center of O'Fallon
O'Fallon, Illinois, 62269
United States
Northwestern Medicine Oak Brook
Oak Brook, Illinois, 60523
United States
Northwestern Medicine Orland Park
Orland Park, Illinois, 60462
United States
University of Chicago Medicine-Orland Park
Orland Park, Illinois, 60462
United States
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois, 61350
United States
Illinois CancerCare-Pekin
Pekin, Illinois, 61554
United States
Illinois CancerCare-Peoria
Peoria, Illinois, 61615
United States
Methodist Medical Center of Illinois
Peoria, Illinois, 61636
United States
Illinois CancerCare-Peru
Peru, Illinois, 61354
United States
Valley Radiation Oncology
Peru, Illinois, 61354
United States
Illinois CancerCare-Princeton
Princeton, Illinois, 61356
United States
Southern Illinois University School of Medicine
Springfield, Illinois, 62702
United States
Springfield Clinic
Springfield, Illinois, 62702
United States
Springfield Memorial Hospital
Springfield, Illinois, 62781
United States
Carle Cancer Center
Urbana, Illinois, 61801
United States
The Carle Foundation Hospital
Urbana, Illinois, 61801
United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, 60555
United States
Memorial Hospital of South Bend
South Bend, Indiana, 46601
United States
Mary Greeley Medical Center
Ames, Iowa, 50010
United States
McFarland Clinic - Ames
Ames, Iowa, 50010
United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, Iowa, 50023
United States
Iowa Methodist Medical Center
Des Moines, Iowa, 50309
United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, Iowa, 50309
United States
Broadlawns Medical Center
Des Moines, Iowa, 50314
United States
Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314
United States
Iowa Lutheran Hospital
Des Moines, Iowa, 50316
United States
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, 52242
United States
Methodist West Hospital
West Des Moines, Iowa, 50266-7700
United States
Baptist Health Lexington
Lexington, Kentucky, 40503
United States
University of Kentucky/Markey Cancer Center
Lexington, Kentucky, 40536
United States
The James Graham Brown Cancer Center at University of Louisville
Louisville, Kentucky, 40202
United States
Baptist Health Louisville
Louisville, Kentucky, 40207
United States
Baptist Health Madisonville/Merle Mahr Cancer Center
Madisonville, Kentucky, 42431
United States
LSU Health Baton Rouge-North Clinic
Baton Rouge, Louisiana, 70805
United States
Our Lady of the Lake Physician Group
Baton Rouge, Louisiana, 70808
United States
Louisiana Hematology Oncology Associates LLC
Baton Rouge, Louisiana, 70809
United States
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana, 70809
United States
Medical Center of Baton Rouge
Baton Rouge, Louisiana, 70816
United States
Ochsner High Grove
Baton Rouge, Louisiana, 70836
United States
Northshore Oncology Associates-Covington
Covington, Louisiana, 70433
United States
Ochsner Hematology Oncology North Shore - Covington (West Region)
Covington, Louisiana, 70433
United States
Terrebonne General Medical Center
Houma, Louisiana, 70360
United States
Ochsner Medical Center Kenner
Kenner, Louisiana, 70065
United States
University Medical Center New Orleans
New Orleans, Louisiana, 70112
United States
Ochsner Medical Center Jefferson
New Orleans, Louisiana, 70121
United States
Greater Baltimore Medical Center
Baltimore, Maryland, 21204
United States
UM Saint Joseph Medical Center
Towson, Maryland, 21204
United States
Tufts Medical Center
Boston, Massachusetts, 02111
United States
Massachusetts General Hospital Cancer Center
Boston, Massachusetts, 02114
United States
Boston Medical Center
Boston, Massachusetts, 02118
United States
Dana-Farber Cancer Institute
Boston, Massachusetts, 02215
United States
Lahey Hospital and Medical Center
Burlington, Massachusetts, 01805
United States
Lahey Medical Center-Peabody
Peabody, Massachusetts, 01960
United States
Hickman Cancer Center
Adrian, Michigan, 49221
United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan, 48106
United States
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, 48109
United States
Trinity Health Medical Center - Brighton
Brighton, Michigan, 48114
United States
Trinity Health Medical Center - Canton
Canton, Michigan, 48188
United States
Chelsea Hospital
Chelsea, Michigan, 48118
United States
Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, 48201
United States
Henry Ford Hospital
Detroit, Michigan, 48202
United States
Henry Ford Health Saint John Hospital
Detroit, Michigan, 48236
United States
Weisberg Cancer Treatment Center
Farmington Hills, Michigan, 48334
United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, Michigan, 49503
United States
West Michigan Cancer Center
Kalamazoo, Michigan, 49007
United States
Henry Ford Health Providence Novi Hospital
Novi, Michigan, 48374
United States
Corewell Health William Beaumont University Hospital
Royal Oak, Michigan, 48073
United States
MyMichigan Medical Center Saginaw
Saginaw, Michigan, 48601
United States
Henry Ford Health Providence Southfield Hospital
Southfield, Michigan, 48075
United States
Corewell Health Beaumont Troy Hospital
Troy, Michigan, 48085
United States
Henry Ford Health Warren Hospital
Warren, Michigan, 48093
United States
Baptist Cancer Center-Grenada
Grenada, Mississippi, 38901
United States
Baptist Memorial Hospital and Cancer Center-Union County
New Albany, Mississippi, 38652
United States
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford, Mississippi, 38655
United States
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, Mississippi, 38671
United States
Mercy Oncology and Hematology - Clayton-Clarkson
Ballwin, Missouri, 63011
United States
Mercy Cancer Center - Cape Girardeau
Cape Girardeau, Missouri, 63703
United States
Saint Francis Medical Center
Cape Girardeau, Missouri, 63703
United States
MU Health - University Hospital/Ellis Fischel Cancer Center
Columbia, Missouri, 65212
United States
MU Health Care Goldschmidt Cancer Center
Jefferson City, Missouri, 65109
United States
Mercy Hospital Joplin
Joplin, Missouri, 64804
United States
Saint Luke's Hospital of Kansas City
Kansas City, Missouri, 64111
United States
Mercy Clinic-Rolla-Cancer and Hematology
Rolla, Missouri, 65401
United States
Phelps Health Delbert Day Cancer Institute
Rolla, Missouri, 65401
United States
Heartland Regional Medical Center
Saint Joseph, Missouri, 64506
United States
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri, 63670
United States
Mercy Hospital Springfield
Springfield, Missouri, 65804
United States
CoxHealth South Hospital
Springfield, Missouri, 65807
United States
Washington University School of Medicine
St Louis, Missouri, 63110
United States
Mercy Hospital South
St Louis, Missouri, 63128
United States
Missouri Baptist Medical Center
St Louis, Missouri, 63131
United States
Mercy Hospital Saint Louis
St Louis, Missouri, 63141
United States
Missouri Baptist Sullivan Hospital
Sullivan, Missouri, 63080
United States
BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri, 63127
United States
Billings Clinic Cancer Center
Billings, Montana, 59101
United States
Bozeman Health Deaconess Hospital
Bozeman, Montana, 59715
United States
Benefis Sletten Cancer Institute
Great Falls, Montana, 59405
United States
Great Falls Clinic
Great Falls, Montana, 59405
United States
Logan Health Medical Center
Kalispell, Montana, 59901
United States
Community Medical Center
Missoula, Montana, 59804
United States
Nebraska Methodist Hospital
Omaha, Nebraska, 68114
United States
OptumCare Cancer Care at Charleston
Las Vegas, Nevada, 89102
United States
Renown Regional Medical Center
Reno, Nevada, 89502
United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire, 03756
United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, 07920
United States
Cooper Hospital University Medical Center
Camden, New Jersey, 08103
United States
Englewood Hospital and Medical Center
Englewood, New Jersey, 07631
United States
Jersey City Medical Center
Jersey City, New Jersey, 07302
United States
Monmouth Medical Center Southern Campus
Lakewood, New Jersey, 08701
United States
Saint Barnabas Medical Center
Livingston, New Jersey, 07039
United States
Monmouth Medical Center
Long Branch, New Jersey, 07740
United States
Memorial Sloan Kettering Monmouth
Middletown, New Jersey, 07748
United States
Memorial Sloan Kettering Bergen
Montvale, New Jersey, 07645
United States
Jersey Shore Medical Center
Neptune City, New Jersey, 07753
United States
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903
United States
The Valley Hospital - Luckow Pavilion
Paramus, New Jersey, 07652
United States
Valley Health System Ridgewood Campus
Ridgewood, New Jersey, 07450
United States
Holy Name Hospital
Teaneck, New Jersey, 07666
United States
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87106
United States
Northwell Health Imbert Cancer Center
Bay Shore, New York, 11706
United States
South Shore University Hospital
Bay Shore, New York, 11706
United States
Memorial Sloan Kettering Commack
Commack, New York, 11725
United States
The Cancer Institute at Saint Francis Hospital
East Hills, New York, 11548
United States
Hematology Oncology Associates of Central New York-East Syracuse
East Syracuse, New York, 13057
United States
Northwell Health Cancer Institute at Huntington
Greenlawn, New York, 11740
United States
Memorial Sloan Kettering Westchester
Harrison, New York, 10604
United States
Northwell Health/Center for Advanced Medicine
Lake Success, New York, 11042
United States
North Shore University Hospital
Manhasset, New York, 11030
United States
Long Island Jewish Medical Center
New Hyde Park, New York, 11040
United States
Mount Sinai West
New York, New York, 10019
United States
Mount Sinai Hospital
New York, New York, 10029
United States
Manhattan Eye Ear and Throat Hospital
New York, New York, 10065
United States
Memorial Sloan Kettering Cancer Center
New York, New York, 10065
United States
Lenox Hill Hospital
New York, New York, 10075
United States
Upstate Cancer Center at Oswego
Oswego, New York, 13126
United States
Queens Cancer Center
Rego Park, New York, 11374
United States
University of Rochester
Rochester, New York, 14642
United States
Staten Island University Hospital
Staten Island, New York, 10305
United States
Stony Brook University Medical Center
Stony Brook, New York, 11794
United States
State University of New York Upstate Medical University
Syracuse, New York, 13210
United States
SUNY Upstate Medical Center-Community Campus
Syracuse, New York, 13215
United States
Montefiore Medical Center-Einstein Campus
The Bronx, New York, 10461
United States
Montefiore Medical Center-Weiler Hospital
The Bronx, New York, 10461
United States
Montefiore Medical Center - Moses Campus
The Bronx, New York, 10467
United States
Memorial Sloan Kettering Nassau
Uniondale, New York, 11553
United States
Upstate Cancer Center at Verona
Verona, New York, 13478
United States
Wilmot Cancer Institute at Webster
Webster, New York, 14580
United States
Dickstein Cancer Treatment Center
White Plains, New York, 10601
United States
Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina, 28203
United States
Duke University Medical Center
Durham, North Carolina, 27710
United States
East Carolina University
Greenville, North Carolina, 27834
United States
ECU Health Oncology Kinston
Kinston, North Carolina, 28501
United States
CarolinaEast Medical Center
New Bern, North Carolina, 28561
United States
Duke Women's Cancer Care Raleigh
Raleigh, North Carolina, 27607
United States
Duke Cancer Center Raleigh
Raleigh, North Carolina, 27609
United States
Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157
United States
Sanford Broadway Medical Center
Fargo, North Dakota, 58122
United States
Sanford Roger Maris Cancer Center
Fargo, North Dakota, 58122
United States
Cleveland Clinic Akron General
Akron, Ohio, 44307
United States
Miami Valley Hospital South
Centerville, Ohio, 45459
United States
Adena Regional Medical Center
Chillicothe, Ohio, 45601
United States
Good Samaritan Hospital - Cincinnati
Cincinnati, Ohio, 45220
United States
Case Western Reserve University
Cleveland, Ohio, 44106
United States
MetroHealth Medical Center
Cleveland, Ohio, 44109
United States
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, Ohio, 44111
United States
Cleveland Clinic Foundation
Cleveland, Ohio, 44195
United States
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210
United States
Mount Carmel East Hospital
Columbus, Ohio, 43213
United States
Riverside Methodist Hospital
Columbus, Ohio, 43214
United States
Grant Medical Center
Columbus, Ohio, 43215
United States
The Mark H Zangmeister Center
Columbus, Ohio, 43219
United States
Mount Carmel Health Center West
Columbus, Ohio, 43222
United States
Doctors Hospital
Columbus, Ohio, 43228
United States
Miami Valley Hospital
Dayton, Ohio, 45409
United States
Miami Valley Hospital North
Dayton, Ohio, 45415
United States
Dublin Methodist Hospital
Dublin, Ohio, 43016
United States
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio, 45005-1066
United States
Miami Valley Cancer Care and Infusion
Greenville, Ohio, 45331
United States
Mount Carmel Grove City Hospital
Grove City, Ohio, 43123
United States
OhioHealth Mansfield Hospital
Mansfield, Ohio, 44903
United States
Cleveland Clinic Cancer Center Mansfield
Mansfield, Ohio, 44906
United States
Marietta Memorial Hospital
Marietta, Ohio, 45750
United States
Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio, 44124
United States
Licking Memorial Hospital
Newark, Ohio, 43055
United States
Newark Radiation Oncology
Newark, Ohio, 43055
United States
Southern Ohio Medical Center
Portsmouth, Ohio, 45662
United States
North Coast Cancer Care
Sandusky, Ohio, 44870
United States
University of Toledo
Toledo, Ohio, 43614
United States
Toledo Clinic Cancer Centers-Toledo
Toledo, Ohio, 43623
United States
Upper Valley Medical Center
Troy, Ohio, 45373
United States
Saint Ann's Hospital
Westerville, Ohio, 43081
United States
Cleveland Clinic Wooster Family Health and Surgery Center
Wooster, Ohio, 44691
United States
Genesis Healthcare System Cancer Care Center
Zanesville, Ohio, 43701
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104
United States
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma, 73120
United States
Saint Charles Health System
Bend, Oregon, 97701
United States
Clackamas Radiation Oncology Center
Clackamas, Oregon, 97015
United States
Providence Cancer Institute Clackamas Clinic
Clackamas, Oregon, 97015
United States
Bay Area Hospital
Coos Bay, Oregon, 97420
United States
Providence Newberg Medical Center
Newberg, Oregon, 97132
United States
Providence Willamette Falls Medical Center
Oregon City, Oregon, 97045
United States
Providence Portland Medical Center
Portland, Oregon, 97213
United States
Providence Saint Vincent Medical Center
Portland, Oregon, 97225
United States
Kaiser Permanente Northwest
Portland, Oregon, 97227
United States
Oregon Health and Science University
Portland, Oregon, 97239
United States
Jefferson Abington Hospital
Abington, Pennsylvania, 19001
United States
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania, 18103
United States
Ephrata Cancer Center
Ephrata, Pennsylvania, 17522
United States
Saint Vincent Hospital
Erie, Pennsylvania, 16544
United States
Adams Cancer Center
Gettysburg, Pennsylvania, 17325
United States
Penn State Milton S Hershey Medical Center
Hershey, Pennsylvania, 17033-0850
United States
Jefferson Hospital
Jefferson Hills, Pennsylvania, 15025
United States
Sechler Family Cancer Center
Lebanon, Pennsylvania, 17042
United States
Forbes Hospital
Monroeville, Pennsylvania, 15146
United States
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107
United States
Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212
United States
West Penn Hospital
Pittsburgh, Pennsylvania, 15224
United States
Guthrie Medical Group PC-Robert Packer Hospital
Sayre, Pennsylvania, 18840
United States
Reading Hospital
West Reading, Pennsylvania, 19611
United States
Wexford Health and Wellness Pavilion
Wexford, Pennsylvania, 15090
United States
Asplundh Cancer Pavilion
Willow Grove, Pennsylvania, 19090
United States
WellSpan Health-York Cancer Center
York, Pennsylvania, 17403
United States
WellSpan Health-York Hospital
York, Pennsylvania, 17403
United States
Smilow Cancer Hospital Care Center - Westerly
Westerly, Rhode Island, 02891
United States
Ralph H Johnson VA Medical Center
Charleston, South Carolina, 29401
United States
Medical University of South Carolina
Charleston, South Carolina, 29425
United States
Prisma Health Cancer Institute - Faris
Greenville, South Carolina, 29605
United States
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina, 29615
United States
Prisma Health Cancer Institute - Greer
Greer, South Carolina, 29650
United States
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina, 29672
United States
Avera Cancer Institute-Aberdeen
Aberdeen, South Dakota, 57401
United States
Avera Cancer Institute - Mitchell
Mitchell, South Dakota, 57301
United States
Avera Cancer Institute at Pierre
Pierre, South Dakota, 57501
United States
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota, 57104
United States
Avera Cancer Institute
Sioux Falls, South Dakota, 57105
United States
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, 57117-5134
United States
Avera Cancer Institute at Yankton
Yankton, South Dakota, 57078
United States
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville, Tennessee, 38017
United States
University of Tennessee - Knoxville
Knoxville, Tennessee, 37920
United States
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee, 38120
United States
The Don and Sybil Harrington Cancer Center
Amarillo, Texas, 79106
United States
UT Southwestern Simmons Cancer Center - RedBird
Dallas, Texas, 75237
United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390
United States
UT Southwestern/Simmons Cancer Center-Fort Worth
Fort Worth, Texas, 76104
United States
UT Southwestern Clinical Center at Richardson/Plano
Richardson, Texas, 75080
United States
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78229
United States
University of Vermont Medical Center
Burlington, Vermont, 05401
United States
Inova Schar Cancer Institute
Fairfax, Virginia, 22031
United States
Inova Fair Oaks Hospital
Fairfax, Virginia, 22033
United States
Inova Fairfax Hospital
Falls Church, Virginia, 22042
United States
Inova Loudoun Hospital
Leesburg, Virginia, 20176
United States
Sentara Leigh Hospital
Norfolk, Virginia, 23502
United States
Sentara Norfolk General Hospital
Norfolk, Virginia, 23507
United States
VCU Massey Comprehensive Cancer Center
Richmond, Virginia, 23298
United States
Carilion Roanoke Memorial Hospital
Roanoke, Virginia, 24033
United States
VCU Community Memorial Health Center
South Hill, Virginia, 23970
United States
Providence Regional Cancer System-Aberdeen
Aberdeen, Washington, 98520
United States
Overlake Medical Center
Bellevue, Washington, 98004
United States
PeaceHealth Saint Joseph Medical Center
Bellingham, Washington, 98225
United States
Providence Regional Cancer System-Centralia
Centralia, Washington, 98531
United States
Swedish Cancer Institute-Edmonds
Edmonds, Washington, 98026
United States
Providence Regional Cancer Partnership
Everett, Washington, 98201
United States
Swedish Cancer Institute-Issaquah
Issaquah, Washington, 98029
United States
Providence Regional Cancer System-Lacey
Lacey, Washington, 98503
United States
PeaceHealth Saint John Medical Center
Longview, Washington, 98632
United States
Swedish Medical Center-Ballard Campus
Seattle, Washington, 98107
United States
Fred Hutchinson Cancer Center
Seattle, Washington, 98109
United States
Swedish Medical Center-First Hill
Seattle, Washington, 98122
United States
University of Washington Medical Center - Montlake
Seattle, Washington, 98195
United States
PeaceHealth United General Medical Center
Sedro-Woolley, Washington, 98284
United States
PeaceHealth Southwest Medical Center
Vancouver, Washington, 98664
United States
Providence Saint Mary Regional Cancer Center
Walla Walla, Washington, 99362
United States
West Virginia University Charleston Division
Charleston, West Virginia, 25304
United States
Edwards Comprehensive Cancer Center
Huntington, West Virginia, 25701
United States
Langlade Hospital and Cancer Center
Antigo, Wisconsin, 54409
United States
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin, 54701
United States
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601
United States
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, 54449
United States
Aspirus Medford Hospital
Medford, Wisconsin, 54451
United States
Ascension Columbia Saint Mary's Hospital Ozaukee
Mequon, Wisconsin, 53097
United States
Ascension Columbia Saint Mary's Hospital - Milwaukee
Milwaukee, Wisconsin, 53211
United States
Marshfield Medical Center - Minocqua
Minocqua, Wisconsin, 54548
United States
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin, 54868
United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin, 54482
United States
Aspirus Regional Cancer Center
Wausau, Wisconsin, 54401
United States
Marshfield Medical Center - Weston
Weston, Wisconsin, 54476
United States
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids, Wisconsin, 54494
United States
Welch Cancer Center
Sheridan, Wyoming, 82801
United States

Collaborators and Investigators

Sponsor: Alliance for Clinical Trials in Oncology

  • Cristina R. Ferrone, MD, STUDY_CHAIR, Massachusetts General Hospital

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-10-13
Study Completion Date2030-11-01

Study Record Updates

Study Start Date2020-10-13
Study Completion Date2030-11-01

Terms related to this study

Additional Relevant MeSH Terms

  • Pancreatic Adenosquamous Carcinoma
  • Resectable Pancreatic Adenocarcinoma
  • Pancreatic Cancer