The Acute Burn ResUscitation Multicenter Prospective Trial

Description

This is a prospective randomized multi-center study which will compare acute fluid resuscitation using a colloid strategy (LR + 5% Albumin) to a crystalloid strategy (LR alone), in adults with an acute burn involving at least 25% of their total body surface area.

Conditions

Burn Injury

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Study Overview

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Study Details

Study overview

This is a prospective randomized multi-center study which will compare acute fluid resuscitation using a colloid strategy (LR + 5% Albumin) to a crystalloid strategy (LR alone), in adults with an acute burn involving at least 25% of their total body surface area.

The Acute Burn ResUscitation Multicenter Prospective Trial (ABRUPT2)

The Acute Burn ResUscitation Multicenter Prospective Trial

Condition
Burn Injury
Intervention / Treatment

-

Contacts and Locations

Phoenix

Arizona Burn Center Valleywise Health, Phoenix, Arizona, United States, 85008

Sacramento

University of California Davis, Regional Burn Center, Sacramento, California, United States, 95817

Torrance

Torrance Memorial, Torrance, California, United States, 90505

Gainesville

University of Florida Health, Gainesville, Florida, United States, 32608

Miami

University of Miami Health System, Miami, Florida, United States, 33136

Tampa

University of South Florida, Tampa, Florida, United States, 33606

Maywood

Loyola Medicine, Maywood, Illinois, United States, 60153

Iowa City

University of Iowa Healthcare, Iowa City, Iowa, United States, 52242

Kansas City

University of Kansas Health System, Kansas City, Kansas, United States, 66160

Wichita

Ascension Via Christi St. Francis, Wichita, Kansas, United States, 67214

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age ≥ 18 years
  • * Total burn size (second and third degree) is ≥ 25% of the TBSA
  • * Burn center admission within 12 hours of injury.
  • * There is a plan for formal fluid resuscitation.
  • * Significant associated trauma
  • * High voltage (≥ 1000 volts) electrical burns
  • * Burn wound excision surgery within 48 hours from injury
  • * Fresh frozen plasma (FFP) given at any time ≤ 48 hours from injury
  • * Hypertonic saline (HTS) given at any time ≤ 48 hours from injury
  • * Hydroxyethyl starch (HES) given at any time ≤ 48 hours from injury
  • * High dose Vitamin C infusion given at any time ≤ 48 hours from injury
  • * Administration of human albumin prior to randomization
  • * Palliative comfort measures are instituted ≤ 48 hours from injury
  • * Pregnancy
  • * Pre-injury chronic renal insufficiency equal to or greater than stage 3
  • * Pre-injury chronic hepatic disease (Child-Pugh B or C)
  • * Pre-injury left ventricular (LV) dysfunction (echocardiography LV grade II-IV or ejection fraction ≤ 35%)

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

American Burn Association,

David G Greenhalgh, MD, PRINCIPAL_INVESTIGATOR, UC Davis Health

Study Record Dates

2025-09