The ExTINGUISH Trial of Inebilizumab in NMDAR Encephalitis

Description

Determine the difference in the modified Rankin score at 16 weeks in participants with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis treated with "first-line" immunomodulatory therapies provided as standard-of-care, and either inebilizumab (investigational agent) or placebo.

Conditions

Autoimmune Encephalitis, Encephalitis

Study Overview

Study Details

Study overview

Determine the difference in the modified Rankin score at 16 weeks in participants with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis treated with "first-line" immunomodulatory therapies provided as standard-of-care, and either inebilizumab (investigational agent) or placebo.

A Phase-2b, Double-Blind, Randomized Controlled Trial to Evaluate the Activity and Safety of Inebilizumab in Anti-Nmda Receptor Encephalitis and Assess Markers of Disease

The ExTINGUISH Trial of Inebilizumab in NMDAR Encephalitis

Condition
Autoimmune Encephalitis
Intervention / Treatment

-

Contacts and Locations

Birmingham

University of Alabama at Birmingham, Birmingham, Alabama, United States, 35233

Phoenix

St. Joseph Hospital and Medical Center Barrow Neurological Institute, Phoenix, Arizona, United States, 85013

Orange

UC Irvine, Orange, California, United States, 92868

Sacramento

UC Davis, Sacramento, California, United States, 95816

New Haven

Yale University, New Haven, Connecticut, United States, 06510

Jacksonville

Mayo Clinic Jacksonville, Jacksonville, Florida, United States, 32224

Miami

University of Miami, Miami, Florida, United States, 33136

Chicago

Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States, 60611

Iowa City

University of Iowa, Iowa City, Iowa, United States, 52242

Boston

Massachusetts General Hospital, Boston, Massachusetts, United States, 02114

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

    Ages Eligible for Study

    12 Years to

    Sexes Eligible for Study

    ALL

    Accepts Healthy Volunteers

    No

    Collaborators and Investigators

    University of Utah,

    Stacey L Clardy, MD, PhD, PRINCIPAL_INVESTIGATOR, University of Utah

    Study Record Dates

    2026-08-31