Atorvastatin ± Aspirin in Lynch Syndrome Syndrome

Description

The goal of this study is to investigate that a common cholesterol lowering agent (atorvastatin) alone or combining with a nonsteroidal anti-inflammatory drug (aspirin) would reduce the risk of colorectal cancer (CRC) in high-risk individuals with Lynch syndrome.

Conditions

Lynch Syndrome

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Study Overview

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Study Details

Study overview

The goal of this study is to investigate that a common cholesterol lowering agent (atorvastatin) alone or combining with a nonsteroidal anti-inflammatory drug (aspirin) would reduce the risk of colorectal cancer (CRC) in high-risk individuals with Lynch syndrome.

Impact of Atorvastatin ± Aspirin on Colorectal Biomarkers in Patients With Lynch Syndrome: a Pilot Study

Atorvastatin ± Aspirin in Lynch Syndrome Syndrome

Condition
Lynch Syndrome
Intervention / Treatment

-

Contacts and Locations

Philadelphia

Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States, 19111

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Subjects who are 18 years of age or older
  • * Able to read and sign an informed consent document in English
  • * Eligible subjects will have molecular evidence of Lynch Syndrome (mutation in MLH1, MSH2, MSH6, EPCAM or PMS2)
  • * History of colorectal cancer if surgically cured and \> 1 year from completion of adjuvant chemotherapy
  • * Are \<18 years of age
  • * Unable to read and sign an informed consent document in English
  • * Have active cancer or are less than 3 years post hormonal maintenance therapy for cancer
  • * Have statin intolerance or contraindication for aspirin or atorvastatin use
  • * Are pregnant or are actively breast feeding

Ages Eligible for Study

18 Years to 75 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Fox Chase Cancer Center,

Michael J Hall, MD, MS, PRINCIPAL_INVESTIGATOR, Fox Chase Cancer Center

Study Record Dates

2024-12-31