Biomechanical and Neural Mechanisms of Post-stroke Gait Training

Description

The study seeks to develop an understanding of how, why, and for whom fast treadmill walking (Fast) and Fast with functional electrical stimulation (FastFES) induce clinical benefits, allowing future development of cutting-edge, individually-tailored gait treatments that enhance both gait quality and gait function.

Conditions

Stroke

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Study Overview

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Study Details

Study overview

The study seeks to develop an understanding of how, why, and for whom fast treadmill walking (Fast) and Fast with functional electrical stimulation (FastFES) induce clinical benefits, allowing future development of cutting-edge, individually-tailored gait treatments that enhance both gait quality and gait function.

Biomechanical and Neural Mechanisms of Post-stroke Gait Training

Biomechanical and Neural Mechanisms of Post-stroke Gait Training

Condition
Stroke
Intervention / Treatment

-

Contacts and Locations

Atlanta

Emory University Hospital, Atlanta, Georgia, United States, 30322

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * at least 6 months since stroke
  • * single cortical or subcortical ischemic stroke
  • * able to walk 10-meters with or without assistive device
  • * sufficient cardiovascular health and ankle stability to walk on treadmill for 2-minutes at self-selected speed without orthosis
  • * resting heart rate 40-100 bpm
  • * hemorrhagic stroke
  • * cerebellar signs (ataxic ("drunken") gait or decreased coordination during rapid alternating hand or foot movements
  • * score of \>1 on question 1b and \>0 on question 1c on NIH Stroke Scale
  • * inability to communicate with investigators
  • * musculoskeletal conditions or pain that limit walking
  • * neglect/hemianopia, or unexplained dizziness in last 6 months
  • * neurologic conditions or diagnoses other than stroke
  • * lack of sensation in lower limb affected by stroke
  • * any medical diagnosis that would hinder the participant from completing the experimental trial
  • * additional exclusion criteria due to contra-indications to TMS (measurement of corticospinal excitability) are: history of seizures, metal implants in the head or face, history of recurring or severe headaches/migraine, headache within the past 24 hours, presence of skull abnormalities or fractures, hemorrhagic stroke, history of dizziness, syncope, nausea, or loss of consciousness in the past 6 months

Ages Eligible for Study

40 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Emory University,

Trisha Kesar, PT, PhD, PRINCIPAL_INVESTIGATOR, Emory University

Study Record Dates

2026-04-01