Effects of Combination Exercise on Fatigability in Veterans With Chronic Kidney Disease

Description

The VA health care system uses a health promotion-focused model which aims to provide longitudinal care through a patient-aligned care team for Veterans with chronic kidney disease. Since the largest subpopulation of Veterans with chronic kidney disease is comprised of those not requiring dialysis, neuromuscular screening assessments may provide valuable information regarding an individual overall health status and potential for future complications. Furthermore, identifying at risk individuals early in the disease process will allow for the prescription of timely interventions. Exercise strategies such as combination exercise, which uses flywheel resistance plus aerobic exercise, may provide a valuable treatment option for combating neuromuscular dysfunction and functional decline in patients with chronic kidney disease.

Conditions

Chronic Kidney Disease Predialysis

Talk to us

Study Overview

On this page

Study Details

Study overview

The VA health care system uses a health promotion-focused model which aims to provide longitudinal care through a patient-aligned care team for Veterans with chronic kidney disease. Since the largest subpopulation of Veterans with chronic kidney disease is comprised of those not requiring dialysis, neuromuscular screening assessments may provide valuable information regarding an individual overall health status and potential for future complications. Furthermore, identifying at risk individuals early in the disease process will allow for the prescription of timely interventions. Exercise strategies such as combination exercise, which uses flywheel resistance plus aerobic exercise, may provide a valuable treatment option for combating neuromuscular dysfunction and functional decline in patients with chronic kidney disease.

Objective and Subjective Measures of Fatigability in Veterans With Chronic Kidney Disease Before and After Flywheel Resistance Plus Aerobic Exercise

Effects of Combination Exercise on Fatigability in Veterans With Chronic Kidney Disease

Condition
Chronic Kidney Disease Predialysis
Intervention / Treatment

-

Contacts and Locations

Washington

Washington DC VA Medical Center, Washington, DC, Washington, District of Columbia, United States, 20422-0001

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Ambulatory (with or without a gait aid), 50 years of age or older diagnosed with chronic kidney disease (CKD) stages 3 \& 4 predialysis (as defined by eGFR 59-15 ml/min per 1.73m2)
  • * Control group will include ambulatory individuals without clinical evidence of kidney disease (defined by eGRF \>60 ml/min per 1.73m2) within the last 12-months
  • * All participants must be able to speak and read English, and demonstrate orientation to person, place, and time
  • * adults diagnosed with acute renal failure/injury within the last 12-months
  • * non-ambulatory individuals
  • * adults who do not use the DC VAMC as their main site for renal care
  • * those who have any uncontrolled cardiovascular
  • * musculoskeletal disease
  • * or other conditions that, in the opinion of the principal investigator, could make participation in the study unsafe
  • * any orthopedic or joint pain which would prevent the participant from safely engaging in the study protocol
  • * additionally, individuals with plans to relocate from the DC metro area within one year will not be eligible for the intervention portion of the study

Ages Eligible for Study

50 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

VA Office of Research and Development,

Jared M. Gollie, PhD, PRINCIPAL_INVESTIGATOR, Washington DC VA Medical Center, Washington, DC

Study Record Dates

2026-04-01