RECRUITING

Effects of Combination Exercise on Fatigability in Veterans With Chronic Kidney Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The VA health care system uses a health promotion-focused model which aims to provide longitudinal care through a patient-aligned care team for Veterans with chronic kidney disease. Since the largest subpopulation of Veterans with chronic kidney disease is comprised of those not requiring dialysis, neuromuscular screening assessments may provide valuable information regarding an individual overall health status and potential for future complications. Furthermore, identifying at risk individuals early in the disease process will allow for the prescription of timely interventions. Exercise strategies such as combination exercise, which uses flywheel resistance plus aerobic exercise, may provide a valuable treatment option for combating neuromuscular dysfunction and functional decline in patients with chronic kidney disease.

Official Title

Objective and Subjective Measures of Fatigability in Veterans With Chronic Kidney Disease Before and After Flywheel Resistance Plus Aerobic Exercise

Quick Facts

Study Start:2022-06-01
Study Completion:2026-04-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04397159

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years to 85 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Ambulatory (with or without a gait aid), 50 years of age or older diagnosed with chronic kidney disease (CKD) stages 3 \& 4 predialysis (as defined by eGFR 59-15 ml/min per 1.73m2)
  2. * Control group will include ambulatory individuals without clinical evidence of kidney disease (defined by eGRF \>60 ml/min per 1.73m2) within the last 12-months
  3. * All participants must be able to speak and read English, and demonstrate orientation to person, place, and time
  1. * adults diagnosed with acute renal failure/injury within the last 12-months
  2. * non-ambulatory individuals
  3. * adults who do not use the DC VAMC as their main site for renal care
  4. * those who have any uncontrolled cardiovascular
  5. * musculoskeletal disease
  6. * or other conditions that, in the opinion of the principal investigator, could make participation in the study unsafe
  7. * any orthopedic or joint pain which would prevent the participant from safely engaging in the study protocol
  8. * additionally, individuals with plans to relocate from the DC metro area within one year will not be eligible for the intervention portion of the study

Contacts and Locations

Study Contact

Jared M Gollie, PhD
CONTACT
(202) 745-8000
Jared.Gollie@va.gov

Principal Investigator

Jared M. Gollie, PhD
PRINCIPAL_INVESTIGATOR
Washington DC VA Medical Center, Washington, DC

Study Locations (Sites)

Washington DC VA Medical Center, Washington, DC
Washington, District of Columbia, 20422-0001
United States

Collaborators and Investigators

Sponsor: VA Office of Research and Development

  • Jared M. Gollie, PhD, PRINCIPAL_INVESTIGATOR, Washington DC VA Medical Center, Washington, DC

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-06-01
Study Completion Date2026-04-01

Study Record Updates

Study Start Date2022-06-01
Study Completion Date2026-04-01

Terms related to this study

Keywords Provided by Researchers

  • fatigability
  • strength
  • rehabilitation
  • eccentric exercise
  • combination exercise

Additional Relevant MeSH Terms

  • Chronic Kidney Disease Predialysis