RECRUITING

The Role of MicroRNA in the Diagnosis, Prognosis and Response to Treatment in Pancreatic Cancer

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Aberrant miRNA production has been linked to a wide range of human cancers and shown to play important roles in their genesis and growth. These miRNA can be detected in the blood and tumors of patients with cancer. The investigators hypothesize that the detection of certain miRNAs present in the blood/serum of patients with pancreatic cancer may be important to the early diagnosis of the disease. Furthermore, the investigators hypothesize that miRNA detection in PC patients will yield prognostic information and help predict the response to treatment.

Official Title

The Role of MicroRNA in the Diagnosis, Prognosis and Response to Treatment in Pancreatic Cancer

Quick Facts

Study Start:2015-04
Study Completion:2027-04
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04406831

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Have biopsy proven adenocarcinoma of the pancreas
  2. * Have initially inoperable disease, classified as either locally advanced or metastatic disease
  3. * Recurrent disease after a Whipple procedure is allowed
  4. * Patients who are able to undergo resection after neoadjuvant therapy will continue to be followed after resection
  5. * Have radiographically measurable disease
  6. * Have an ECOG performance status of 2 or less
  7. * Be willing to contribute the required information and specimens
  8. * Provide written signed consent to participate
  1. * Having received prior anti-cancer treatments for metastatic pancreatic cancer
  2. * Concurrently receiving systemic therapy for another cancer except androgen deprivation therapy for stable/controlled prostate cancer
  3. * Presence of other active cancer except for: adequately treated local basal or squamous cell carcinoma of the skin, cervical carcinoma in situ, superficial bladder cancer, asymptomatic prostate cancer without known metastatic disease and with no requirement for therapy or requiring only hormonal therapy and with normal prostate-specific antigen for \>1 year prior to start of trial. Other adequately treated Stage 1 or 2 cancer currently in complete remission, or any other cancer that has been in complete remission for \> 5 years is allowable

Contacts and Locations

Study Contact

Pramila Krumholtz, RN
CONTACT
pramila.krumholtz@nuvancehealth.org
Tammy Lo, MSN
CONTACT
tammy.lo@nuvancehealth.org

Principal Investigator

Richard Frank, MD
PRINCIPAL_INVESTIGATOR
Nuvance Health

Study Locations (Sites)

Nuvance Health
Norwalk, Connecticut, 06856
United States

Collaborators and Investigators

Sponsor: Nuvance Health

  • Richard Frank, MD, PRINCIPAL_INVESTIGATOR, Nuvance Health

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2015-04
Study Completion Date2027-04

Study Record Updates

Study Start Date2015-04
Study Completion Date2027-04

Terms related to this study

Keywords Provided by Researchers

  • Pancreas
  • Cancer
  • Biomarker

Additional Relevant MeSH Terms

  • Pancreatic Cancer Stage III
  • Pancreatic Cancer Stage IV
  • Pancreatic Ductal Adenocarcinoma
  • Pancreatic Neoplasms