TERMINATED

PVB vs Ketamine/Lidocaine in Rib Fracture Patients

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Rib fractures are a common admission to the trauma service. The mainstay of treatment is pain control to improve respiratory effort in order to offset the risk of pneumonia and mechanical ventilation. In addition to standard pain control modalities, the investigator's institution utilizes paravertebral blocks as well as lidocaine and ketamine infusions for pain control. The current standard of care for pain control is to begin with acetaminophen, ibuprofen or celecoxib and opioids with the addition of paravertebral blocks as needed. In certain situations, a paravertebral block is contraindicated, and pain control is relegated to lidocaine and ketamine infusion. The use of lidocaine infusion alone and ketamine infusion alone for pain control has been studied and has been shown to be safe. However, concurrent use of these two medications to control rib fracture pain is relatively new and the efficacy compared to paravertebral block is not known. The goal of the study is to show non-inferiority of simultaneous lidocaine and ketamine infusions versus paravertebral blocks.

Official Title

Paravertebral Block Versus Simultaneous Ketamine and Lidocaine Infusions for Pain Management in Rib Fracture Patients

Quick Facts

Study Start:2020-09-01
Study Completion:2025-01-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:TERMINATED

Study ID

NCT04413799

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * age 18-80 with rib fracture requiring hospitalization
  2. * Failure of standard pain regimen as determined by RR \> 20, TV \< or equal to 50% predicted, NPS \> or equal to 5, Poor cough
  1. * age less than 18 years
  2. * greater than 80 years
  3. * GCS less than or equal to 13
  4. * intubated at admission
  5. * prior or anticipated exploratory laparotomy during this admission
  6. * prior or expected thoracotomy during this admission
  7. * prior or expected emergent craniotomy during this admission
  8. * spinal cord injury
  9. * pelvic injury that has required or will require operative intervention
  10. * inability to accomplish activities of daily living independently
  11. * pregnancy
  12. * incarceration

Contacts and Locations

Study Locations (Sites)

The George Washington University Hospital
Washington, District of Columbia, 20037
United States

Collaborators and Investigators

Sponsor: George Washington University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-09-01
Study Completion Date2025-01-01

Study Record Updates

Study Start Date2020-09-01
Study Completion Date2025-01-01

Terms related to this study

Additional Relevant MeSH Terms

  • Rib Fractures
  • Rib Trauma
  • Rib Fracture Multiple
  • Pain, Acute