Ovarian Morphology in Girls

Description

Establishment of regular menstrual cycles is a key component of reproductive maturation and a recognized vital sign for health and well-being. Irregular menstrual cycles are especially common for the first 2-3 years after an adolescent's first menstrual period (i.e., menarche), which delays the identification and diagnosis of early reproductive disturbances such as polycystic ovary syndrome (PCOS). The purpose of this research study is to determine whether the ovary can serve as a reliable predictor of normal or abnormal development by following the trajectory of ovarian morphology in conjunction with menstrual cyclicity using 3D transabdominal ultrasound imaging in a prospective cohort study of adolescents. A secondary objective is to identify potential environmental factors such as diet and the gut microbiome which influence the trajectory towards normal or abnormal reproductive development.

Conditions

Amenorrhea, Oligomenorrhea, Puberty

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Study Overview

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Study Details

Study overview

Establishment of regular menstrual cycles is a key component of reproductive maturation and a recognized vital sign for health and well-being. Irregular menstrual cycles are especially common for the first 2-3 years after an adolescent's first menstrual period (i.e., menarche), which delays the identification and diagnosis of early reproductive disturbances such as polycystic ovary syndrome (PCOS). The purpose of this research study is to determine whether the ovary can serve as a reliable predictor of normal or abnormal development by following the trajectory of ovarian morphology in conjunction with menstrual cyclicity using 3D transabdominal ultrasound imaging in a prospective cohort study of adolescents. A secondary objective is to identify potential environmental factors such as diet and the gut microbiome which influence the trajectory towards normal or abnormal reproductive development.

Trajectory of Ovarian Morphology During the Adolescent Reproductive Transition

Ovarian Morphology in Girls

Condition
Amenorrhea
Intervention / Treatment

-

Contacts and Locations

Kansas City

Children's Mercy Hospital, Kansas City, Missouri, United States, 64108

Ithaca

Cornell University - Human Metabolic Research Unit, Ithaca, New York, United States, 14853

Rochester

University of Rochester, Strong Fertility Center, Rochester, New York, United States, 14623

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Female adolescents aged 9 to 17 years
  • * Menarche within 11 months of the enrollment visit
  • * University of Rochester site only: Family history of PCOS (i.e., mother or aunt)
  • * Current or recent use of medications or supplements known or suspected to interfere with reproductive or metabolic function in the past 2 months (e.g., contraceptives, metformin, steroids, anti-seizure medications)
  • * Untreated and/or unstable medical or mental health condition known or suspected to interfere with reproductive or metabolic function
  • * Currently pregnant or breast feeding
  • * History of ovarian surgery
  • * Presence of significant acute or chronic illness which may interfere with study participation

Ages Eligible for Study

9 Years to 17 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Cornell University,

Marla E Lujan, PhD, PRINCIPAL_INVESTIGATOR, Cornell University

Tania Burgert, MD, PRINCIPAL_INVESTIGATOR, Children's Mercy Hospital Kansas City

Romina Barral, MD MSCR FAPP, PRINCIPAL_INVESTIGATOR, Children's Mercy Hospital Kansas City

Kathleen Hoeger, MD, PRINCIPAL_INVESTIGATOR, University of Rochester

Study Record Dates

2025-03-31