New IDEAS: Imaging Dementia-Evidence for Amyloid Scanning Study

Eligibility Criteria

• * Medicare beneficiary with Medicare as primary insurance;
• * Meets clinical criteria for Mild Cognitive Impairment (MCI) or Dementia as defined by the 2018 National Institute on Aging - Alzheimer's Association Research Framework
• * Brain MRI and/or CT within 24 months prior to enrollment;
• * Clinical laboratory assessment (complete blood count \[CBC\], standard blood chemistry profile, thyroid stimulating hormone \[TSH\], vitamin B12) within the 12 months prior to enrollment;
• * Able to tolerate amyloid PET required by protocol, to be performed at a participating PET facility;
• * English or Spanish speaking (for the purposes of informed consent);
• * Willing and able to provide consent. Consent may be by proxy;
• * Neuropsychiatric syndrome can be classified into "clinically typical" or "clinically atypical" categories
• * Normal cognition or subjective complaints that are not verified by cognitive testing or key informant.
• * Knowledge of amyloid status, in the opinion of the referring dementia expert, may cause significant psychological harm or otherwise negatively impact the patient or family.
• * Amyloid status already known to patient or referring clinician based on prior amyloid imaging or cerebrospinal fluid analysis.
• * Current or previous enrollment in an anti-amyloid therapeutic trial.
• * Scan is being ordered solely based on a family history of dementia, presence of apolipoprotein E (ApoE) 4, or in lieu of genotyping for suspected autosomal mutation carriers.
• * Scan being ordered for nonmedical purposes (e.g., legal, insurance coverage, or employment screening).
• * Cancer requiring active therapy (excluding non-melanoma skin cancer).
• * Hip/pelvic fracture within the 12 months prior to enrollment.
• * Body weight exceeds PET scanner weight limit.
• * Currently pregnant or planning to become pregnant within 90 days of registration.
• * Life expectancy less than 24 months based on medical co-morbidities.
• * Residence in a skilled nursing facility (assisted living facility is not an exclusion criterion).