COMPLETED

MAnnitol for Blood Pressure Stability in HemoDialysis (MAP-HD)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This proposal will measure the effects of mannitol administration versus placebo in hypotensive-prone, adult, maintenance hemodialysis patients with respect to changes in patient symptoms and blood pressure stability.

Official Title

MAnnitol for Blood Pressure Stability in HemoDialysis (MAP-HD)

Quick Facts

Study Start:2021-04-06
Study Completion:2024-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT04428372

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Maintenance HD (\>90 days)
  2. * Age ≥18y
  3. * Thrice-weekly HD
  4. * IDH-prone (defined as nadir intra-dialytic SBP \<100 mmHg in ≥30% of sessions in the prior 4 weeks)
  5. * Hematocrit\>21%
  6. * Written informed consent
  1. * Acute myocardial infarction or stroke within one month
  2. * Pre-HD serum potassium \>6.5 mmol/L in last 4 weeks
  3. * Pregnancy
  4. * Institutionalized individuals
  5. * Life expectancy \<2 months
  6. * Planned renal transplant within 2 months
  7. * Active enrollment in another interventional trial
  8. * Known allergy to mannitol

Contacts and Locations

Principal Investigator

Finnian R Mc Causland, MBBCH, MMSc
PRINCIPAL_INVESTIGATOR
Brigham and Women's Hospital

Study Locations (Sites)

Brigham and Women's
Boston, Massachusetts, 02115
United States

Collaborators and Investigators

Sponsor: Brigham and Women's Hospital

  • Finnian R Mc Causland, MBBCH, MMSc, PRINCIPAL_INVESTIGATOR, Brigham and Women's Hospital

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-04-06
Study Completion Date2024-12-31

Study Record Updates

Study Start Date2021-04-06
Study Completion Date2024-12-31

Terms related to this study

Keywords Provided by Researchers

  • hemodialysis

Additional Relevant MeSH Terms

  • Hemodialysis Complication
  • Hemodynamic Instability