TERMINATED

Study of Dietary Composition in Crohn's Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Patients with inflammatory bowel disease (IBD) often have narrowed microbial diversity and altered composition and function of the gut microbiome. We anticipate the anti-inflammatory diet, when compared with the usual diet, to produce favorable changes in these multi-omics profiles. These findings will provide insight into the interactions between diet and host biology, while providing clues on the mechanisms of diet therapy's effect and CD pathogenesis.

Official Title

Impact of Anti-Inflammatory Whole-Food Diet in Crohn's Disease and Predicting Response to Therapy

Quick Facts

Study Start:2020-10-05
Study Completion:2025-03-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:TERMINATED

Study ID

NCT04431700

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 75 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age of 18 to 75 years old
  2. * History of Crohn's Disease (CD) with mild to moderate symptoms and prior biopsy proof
  1. 1. History or current diagnosis of any of the following:
  2. * Stroke or Arrhythmia
  3. * Seizures
  4. * Liver Disease
  5. * Untreated hypertension (High Blood Pressure)
  6. * Active malignancy
  7. * Bleeding disorders
  8. * Heart Disease
  9. * Lung disease
  10. * Previous Heart surgery
  11. * Previous Gastrointestinal Surgery
  12. * Kidney Disease
  13. * Chronic Diarrhea
  14. * End enterostomy
  15. * Bulimia
  16. * Anorexia
  17. * Laxative Abuse
  18. * Endocrine Disorder
  19. * Current history of smoking tobacco
  20. * Urgent need for abdominal sugery
  21. * Severe Malnutrition
  22. * Active alcohol or non-cannabinoid substance abuse
  23. 2. Recent hospitalization within the last 30 days
  24. 3. Currently pregnant of lactating.
  25. 4. Current use probiotics or dietary supplements that would not be willing to discontinue for the length of the study.
  26. 5. Concerns for non-compliance
  27. 6. If currently on immunosuppressants, immunomodulators, cotticosteroids, and/or 5-aminosalicylates, no changes in doses will be permitted during the trial except for tapering of corticosteroids.

Contacts and Locations

Principal Investigator

Zhaoping Li, MD, PhD
PRINCIPAL_INVESTIGATOR
University of California, Los Angeles

Study Locations (Sites)

UCLA Center for Human Nutrition, 1000 Veteran Ave.
Los Angeles, California, 90095
United States

Collaborators and Investigators

Sponsor: University of California, Los Angeles

  • Zhaoping Li, MD, PhD, PRINCIPAL_INVESTIGATOR, University of California, Los Angeles

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-10-05
Study Completion Date2025-03-31

Study Record Updates

Study Start Date2020-10-05
Study Completion Date2025-03-31

Terms related to this study

Keywords Provided by Researchers

  • Crohn's Disease
  • IBD
  • Anti-inflammatory Diet

Additional Relevant MeSH Terms

  • Inflammatory Bowel Diseases
  • Crohn Disease