Study of Dietary Composition in Crohn's Disease

Description

Patients with inflammatory bowel disease (IBD) often have narrowed microbial diversity and altered composition and function of the gut microbiome. We anticipate the anti-inflammatory diet, when compared with the usual diet, to produce favorable changes in these multi-omics profiles. These findings will provide insight into the interactions between diet and host biology, while providing clues on the mechanisms of diet therapy's effect and CD pathogenesis.

Conditions

Inflammatory Bowel Diseases, Crohn Disease

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Study Overview

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Study Details

Study overview

Patients with inflammatory bowel disease (IBD) often have narrowed microbial diversity and altered composition and function of the gut microbiome. We anticipate the anti-inflammatory diet, when compared with the usual diet, to produce favorable changes in these multi-omics profiles. These findings will provide insight into the interactions between diet and host biology, while providing clues on the mechanisms of diet therapy's effect and CD pathogenesis.

Impact of Anti-Inflammatory Whole-Food Diet in Crohn's Disease and Predicting Response to Therapy

Study of Dietary Composition in Crohn's Disease

Condition
Inflammatory Bowel Diseases
Intervention / Treatment

-

Contacts and Locations

Los Angeles

UCLA Center for Human Nutrition, 1000 Veteran Ave., Los Angeles, California, United States, 90095

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age of 18 to 75 years old
  • * History of Crohn's Disease (CD) with mild to moderate symptoms and prior biopsy proof
  • 1. History or current diagnosis of any of the following:
  • * Stroke or Arrhythmia
  • * Seizures
  • * Liver Disease
  • * Untreated hypertension (High Blood Pressure)
  • * Active malignancy
  • * Bleeding disorders
  • * Heart Disease
  • * Lung disease
  • * Previous Heart surgery
  • * Previous Gastrointestinal Surgery
  • * Kidney Disease
  • * Chronic Diarrhea
  • * End enterostomy
  • * Bulimia
  • * Anorexia
  • * Laxative Abuse
  • * Endocrine Disorder
  • * Current history of smoking tobacco
  • * Urgent need for abdominal sugery
  • * Severe Malnutrition
  • * Active alcohol or non-cannabinoid substance abuse
  • 2. Recent hospitalization within the last 30 days
  • 3. Currently pregnant of lactating.
  • 4. Current use probiotics or dietary supplements that would not be willing to discontinue for the length of the study.
  • 5. Concerns for non-compliance
  • 6. If currently on immunosuppressants, immunomodulators, cotticosteroids, and/or 5-aminosalicylates, no changes in doses will be permitted during the trial except for tapering of corticosteroids.

Ages Eligible for Study

18 Years to 75 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, Los Angeles,

Zhaoping Li, MD, PhD, PRINCIPAL_INVESTIGATOR, University of California, Los Angeles

Study Record Dates

2025-05-01