ACTIVE_NOT_RECRUITING

Renal Metabolism of Glycolate to Oxalate

Conditions

Healthy oxalate metabolism kidney stones glycolate isotope tracer study urolithiasis oxalate

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study will determine the contribution of glycolate metabolism to urinary oxalate excretion in healthy subjects, using carbon 13 isotope glycolate tracer technique and a low-oxalate controlled diet.

Official Title

Renal Metabolism of Glycolate to Oxalate

Quick Facts

Study Start:2020-03-12

Study Completion:2027-09-01

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:ACTIVE_NOT_RECRUITING

Study ID

NCT04437225

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 75 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Mentally competent adults, able to read and comprehend the consent form * 18-75 years of age * Body Mass Index (BMI) between 19 and 40 * In good health as judged from a medical history, reported medications, and a complete blood metabolic profile * Acceptable 24 hour urine collections (performed twice for screening)	* History of any hepatic, renal, bowel, or endocrine disease or any other condition that may influence the absorption, transport or urine excretion of ions * Abnormal urine chemistries or blood metabolic profiles * Poor 24 hour urine collections completed during screening, judged by 24 hour urine creatinine excretion (indicative of not collecting all urine in the 24 hour period) * Pregnancy, intention to become pregnant in the near future, or lactation * Aged \<18 or \>75 * BMI \<19 or \>40

Inclusion Criteria

Exclusion Criteria

* Mentally competent adults, able to read and comprehend the consent form
* 18-75 years of age
* Body Mass Index (BMI) between 19 and 40
* In good health as judged from a medical history, reported medications, and a complete blood metabolic profile
* Acceptable 24 hour urine collections (performed twice for screening)

* History of any hepatic, renal, bowel, or endocrine disease or any other condition that may influence the absorption, transport or urine excretion of ions
* Abnormal urine chemistries or blood metabolic profiles
* Poor 24 hour urine collections completed during screening, judged by 24 hour urine creatinine excretion (indicative of not collecting all urine in the 24 hour period)
* Pregnancy, intention to become pregnant in the near future, or lactation
* Aged \<18 or \>75
* BMI \<19 or \>40

Contacts and Locations

Principal Investigator

Sonia Fargue, M.D., Ph.D.

PRINCIPAL_INVESTIGATOR

University of Alabama at Birmingham

Study Locations (Sites)

University of Alabama at Birmingham

Birmingham, Alabama, 35233

United States

Collaborators and Investigators

Sponsor: University of Alabama at Birmingham

Sonia Fargue, M.D., Ph.D., PRINCIPAL_INVESTIGATOR, University of Alabama at Birmingham

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-03-12

Study Completion Date2027-09-01

Study Record Updates

Study Start Date2020-03-12

Study Completion Date2027-09-01

Terms related to this study

Keywords Provided by Researchers

oxalate metabolism
kidney stones
glycolate
isotope tracer study
urolithiasis
oxalate

Additional Relevant MeSH Terms

Healthy