Renal Metabolism of Glycolate to Oxalate

Description

This study will determine the contribution of glycolate metabolism to urinary oxalate excretion in healthy subjects, using carbon 13 isotope glycolate tracer technique and a low-oxalate controlled diet.

Conditions

Healthy

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Study Overview

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Study Details

Study overview

This study will determine the contribution of glycolate metabolism to urinary oxalate excretion in healthy subjects, using carbon 13 isotope glycolate tracer technique and a low-oxalate controlled diet.

Renal Metabolism of Glycolate to Oxalate

Renal Metabolism of Glycolate to Oxalate

Condition
Healthy
Intervention / Treatment

-

Contacts and Locations

Birmingham

University of Alabama at Birmingham, Birmingham, Alabama, United States, 35233

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Mentally competent adults, able to read and comprehend the consent form
  • * 18-75 years of age
  • * Body Mass Index (BMI) between 19 and 40
  • * In good health as judged from a medical history, reported medications, and a complete blood metabolic profile
  • * Acceptable 24 hour urine collections (performed twice for screening)
  • * History of any hepatic, renal, bowel, or endocrine disease or any other condition that may influence the absorption, transport or urine excretion of ions
  • * Abnormal urine chemistries or blood metabolic profiles
  • * Poor 24 hour urine collections completed during screening, judged by 24 hour urine creatinine excretion (indicative of not collecting all urine in the 24 hour period)
  • * Pregnancy, intention to become pregnant in the near future, or lactation
  • * Aged \<18 or \>75
  • * BMI \<19 or \>40

Ages Eligible for Study

18 Years to 75 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Alabama at Birmingham,

Sonia Fargue, M.D., Ph.D., PRINCIPAL_INVESTIGATOR, University of Alabama at Birmingham

Study Record Dates

2025-12-01