fMRI and IVCM Cornea Microscopy of CXL in Keratoconus

Description

Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).

Conditions

Pain, Postoperative, Pain, Chronic, Pain, Acute, Surgical Injury, Surgical Wound, Cornea Injury, Cornea, Keratoconus

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Study Overview

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Study Details

Study overview

Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).

Neuroplasticity of Pain Pathways and Corneal Afferent Regeneration Following Corneal Crosslinking (CXL) in Keratoconus

fMRI and IVCM Cornea Microscopy of CXL in Keratoconus

Condition
Pain, Postoperative
Intervention / Treatment

-

Contacts and Locations

Boston

Boston Children's Hospital, Boston, Massachusetts, United States, 02115

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 8-35 years
  • * Clinical diagnosis of keratoconus and seeking CXL treatment
  • * English speaking ability sufficient to comprehend consent with parental assistance
  • * MRI compatible
  • * Ability to lie still for an MRI session (60 minutes)
  • * Age 8-35 years
  • * No diagnosis of keratoconus
  • * English speaking ability sufficient to comprehend consent with parental assistance
  • * MRI compatible
  • * Ability to lie still for an MRI session (60 minutes)
  • * Claustrophobic
  • * Weight \> 285 lbs (weight limit of the MRI table)
  • * Significant medical history, including:
  • * Magnetic implants or metal-containing tattoos on their chest or above
  • * Pregnancy
  • * History of contact lens wear
  • * Any allergic response to a numbing eyedrop in the past

Ages Eligible for Study

8 Years to 35 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Boston Children's Hospital,

Eric A Moulton, OD PhD, PRINCIPAL_INVESTIGATOR, Boston Children's Hospital

Study Record Dates

2025-12