Targeting Reactive Oxygen Species Production as a Novel Therapeutic in Fuch's Endothelial Corneal Dystrophy

Eligibility Criteria

• 1. Male or female ≥21 years of age at time of surgical evaluation.
• 2. Diagnosis of advanced FECD and visually significant cataract
• 3. Indication for DMEK (Descemet Membrane Endothelial Keratoplasty) with concurrent cataract surgery
• 4. Written informed consent obtained from subject and ability for subject to comply with the requirements of the study.
• 5. Willingness and ability to adhere to medication regimen
• 1. Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study.
• 2. History of prior intraocular surgery in study eye including cataract, glaucoma and/or retina surgery
• 3. History of other corneal diseases, such as severe dry eye, corneal scars, pseudophakic bullous keratopathy, corneal degenerations, corneal infections
• 4. Use of ocular prescription medications except for lubricants, hyperosmotic agents, or ocular hypotensive agents
• 5. History of ocular surface infection within the past 30 days
• 6. Use of systemic, inhalational, or topical N-Acetylcysteine within the past 30 days
• 7. History of intolerance to topical N-Acetylcysteine
• 8. Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data.