Mechanisms and Modulation of Pain Modulatory Capacity

Description

This project proposes to understand the sources of pain variability, and demonstrate that pain variability represents fluctuation in natural pain management. The project further proposes to determine if endogenous capacity to modulate pain can be trained to maximize their body's ability to manage pain, much as the way in which athletic performance can be trained.

Conditions

Musculoskeletal Pain

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Study Overview

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Study Details

Study overview

This project proposes to understand the sources of pain variability, and demonstrate that pain variability represents fluctuation in natural pain management. The project further proposes to determine if endogenous capacity to modulate pain can be trained to maximize their body's ability to manage pain, much as the way in which athletic performance can be trained.

Mechanisms and Modulation of Pain Modulatory Capacity

Mechanisms and Modulation of Pain Modulatory Capacity

Condition
Musculoskeletal Pain
Intervention / Treatment

-

Contacts and Locations

Gainesville

Unversity of Florida, Gainesville, Florida, United States, 32611

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Asymptomatic people (ie no current pain conditions)
  • * Participants with widespread muscle pain (WMP) aged 18 years of age and older
  • * Participants with WMP must meet the ACR (2010) diagnostic criteria of multiple regions of muscle pain
  • * The asymptomatic group will be free of current wrist/hand, elbow, or shoulder pain and chronic pain conditions (eg irritable bowel syndrome, FM)
  • 1. Participation in a conditioning program specific to the biceps in the past 6 months
  • 2. Any report of wrist/hand, elbow, or shoulder pain in the last 3 months
  • 3. Any chronic medical conditions that may affect pain perception (e.g., diabetes, high blood pressure), kidney dysfunction, muscle damage, or major psychiatric disorder
  • 4. Use of any intervention (including but not limited to medication, massage, and stretching) for symptoms induced by pain training for the duration of the study
  • 5. Positive result on pre-MRI metal screening or pregnancy test due to contraindication for the MRI environment.
  • 6. Any participant with ferromagnetic metal in the head, neck, or abdominal cavity

Ages Eligible for Study

18 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Florida,

Michael E Robinson, PhD, PRINCIPAL_INVESTIGATOR, University of Florida

Study Record Dates

2025-05-01