Phase IIa Trial of a Selective Glucocorticoid Receptor Antagonist in the Treatment of Veterans With Posttraumatic Stress Disorder (PTSD) (Seven Study)

Eligibility Criteria

• * History of US military service
• * Capable of reading and understanding English
• * Able to provide written informed consent
• * Symptoms of PTSD (must score 23 or greater on the CAPS-5 assessment at screening visit)
• * Men and pre-menopausal women must agree to use two forms of reliable contraception, one of which is a barrier method.
• * Participants who use an SSRI or SNRI medication for PTSD must be on a stable dose for 8 weeks before enrollment.
• * Participants who use trazodone for sleep must be on a stable dose.
• * Participants who use opiate pain medication must be on a stable dose.
• * For participants who are in psychotherapy, treatment must be stable for 6 weeks.
• * Alcohol use that meets criteria for Alcohol Use Disorder in past 3 months.
• * Marijuana or other drug use that meets criteria for Substance Use Disorder in past 3 months.
• * Ever diagnosed with: Bipolar Disorder, Schizophrenia, Schizoaffective Disorder, Obsessive-Compulsive Disorder, or Major Depressive Disorder with Psychotic Features
• * Experienced any psychologically traumatic event in the past 3 months
• * Currently using certain antidepressant medications such as doxepin or tricyclics
• * Currently using certain mood stabilizers, such as lithium
• * Currently using antipsychotic medication
• * High risk for suicide or violent behavior
• * Has sleep apnea and not using any treatment, such as CPAP
• * Currently using corticosteroid medication (oral or inhaled)
• * History of neurological disease
• * Angina, congestive heart failure or low blood pressure
• * Heart attack in the past 6 months
• * Heart block or irregular heartbeat
• * Kidney failure, liver failure or pancreatitis
• * Severe chronic obstructive pulmonary disease (COPD)
• * History of liver disease with lab results on AST or ALT more than 2 times the normal readings
• * History of kidney disease with lab results on eGFR less than 60 ml/min
• * History of additional risk factors for Torsades de pointes, such as heart failure, low potassium, or family history of a heart rhythm disorder called long QT syndrome
• * Use of certain medications that can affect heart rhythm
• * Use of certain medications that can interfere with the effects of the study drug
• * High blood pressure that is not controlled by medication
• * Diabetes that is not well-controlled
• * History of certain types of head injuries
• * Mild cognitive impairment