ACTIVE_NOT_RECRUITING

Biomarkers of CASH

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The project aims to develop prognostic and diagnostic blood tests for symptomatic brain hemorrhage in patients diagnosed with cavernous angiomas, a critical clinical challenge in a disease affecting more than a million Americans. We further examine whether blood biomarkers can replace or enhance the accuracy of advanced imaging in association with lesional bleeding. The project tests a novel integrational approach of biomarker development in a mechanistically defined cerebrovascular disease, with a clinically relevant context of use.

Official Title

Biomarkers of Cerebral Cavernous Angioma With Symptomatic Hemorrhage (CASH)

Quick Facts

Study Start:2020-05-22
Study Completion:2026-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT04467489

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Clinical diagnosis of CA
  2. 2. age 18 or older
  3. 3. solitary or multiple
  4. 4. familial or sporadic
  5. 5. with or without prior symptoms
  1. 1. Prior excision of a solitary CA lesion
  2. 2. prior stereotactic radiosurgery or any brain irradiation
  3. 3. spinal cavernoma without brain lesion
  4. 4. other brain pathology unrelated to CA (demyelinating disease, brain tumor)
  5. 5. seizures or stroke unrelated to CA in the prior year
  6. 6. current pregnancy or within 6 months postpartum
  7. 7. reluctance to undergo venipuncture or donate blood specimen, or be called for clinical follow-up for up to one year
  8. 8. homeless or incarcerated persons, or other reason a subject will be unable/unlikely to be reached for follow-up

Contacts and Locations

Principal Investigator

Issam Awad, MD
PRINCIPAL_INVESTIGATOR
University of Chicago

Study Locations (Sites)

Barrow Neurological Institute at St. Joseph's Hospital and Medical Center
Phoenix, Arizona, 85013
United States
University of California, San Francisco
San Francisco, California, 94117
United States
The University of Chicago Medical Center
Chicago, Illinois, 60637
United States
Mayo Clinic
Rochester, Minnesota, 55905
United States

Collaborators and Investigators

Sponsor: University of Chicago

  • Issam Awad, MD, PRINCIPAL_INVESTIGATOR, University of Chicago

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-05-22
Study Completion Date2026-06-30

Study Record Updates

Study Start Date2020-05-22
Study Completion Date2026-06-30

Terms related to this study

Keywords Provided by Researchers

  • plasma biomarker
  • imaging biomarker
  • machine learning

Additional Relevant MeSH Terms

  • Cerebral Cavernous Malformation
  • Cavernous Angioma
  • Hemorrhagic Microangiopathy