Impact of Sinus Surgery on Individuals With Cystic Fibrosis

Description

This study will be a prospective, observational study of patients who undergo endoscopic sinus surgery for cystic fibrosis-related chronic rhinosinusitis (CRS). Individuals who do not undergo surgery but are treated medically for CRS will also be enrolled to serve as a control group. Outcomes analyzed will include pulmonary, quality of life, and others.

Conditions

Chronic Rhinosinusitis (Diagnosis), Cystic Fibrosis

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Study Overview

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Study Details

Study overview

This study will be a prospective, observational study of patients who undergo endoscopic sinus surgery for cystic fibrosis-related chronic rhinosinusitis (CRS). Individuals who do not undergo surgery but are treated medically for CRS will also be enrolled to serve as a control group. Outcomes analyzed will include pulmonary, quality of life, and others.

The Impact of Sinus Surgery in the Era of Highly Effective Modulatory Therapy

Impact of Sinus Surgery on Individuals With Cystic Fibrosis

Condition
Chronic Rhinosinusitis (Diagnosis)
Intervention / Treatment

-

Contacts and Locations

Los Angeles

University of California, Los Angeles, Los Angeles, California, United States, 90095

Stanford

Stanford University, Stanford, California, United States, 94305

Aurora

University of Colorado, Aurora, Colorado, United States, 80045

Denver

National Jewish Health, Denver, Colorado, United States, 80206

Chapel Hill

University of North Carolina, Chapel Hill, North Carolina, United States, 27514

Portland

Oregon Health Science University, Portland, Oregon, United States, 97239

Charleston

Medical University of South Carolina, Charleston, South Carolina, United States, 29425

Nashville

Vanderbilt University Medical Center, Nashville, Tennessee, United States, 37232

Salt Lake City

University of Utah, Salt Lake City, Utah, United States, 84132

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Subjects between the ages of 18 years old (inclusive) and 99 years old (inclusive, subjects over the age of 89 will be recorded to be 89 years old).
  • 2. Diagnosed with cystic fibrosis as established by genetic testing combined with clinical assessment and/or sweat chloride
  • 3. Diagnosed with chronic rhinosinusitis by multidisciplinary sinusitis guidelines
  • 4. chronic rhinosinusitis symptoms persisting beyond initial medical treatment
  • 5. Counseled for endoscopic sinus surgery and ongoing medical therapy with each patient electing their preferred treatment
  • 1. Underwent endoscopic sinus surgery in past 12 months
  • 2. Will obtain follow up care at non-participating institutions
  • 3. Unable to complete follow-up surveys

Ages Eligible for Study

18 Years to 99 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, Los Angeles,

Daniel M Beswick, MD, PRINCIPAL_INVESTIGATOR, University of California, Los Angeles

Study Record Dates

2025-01-31