Prostate Cancer Screening for People at Genetic Risk for Aggressive Disease, PATROL Study

Description

This study investigates ways to detect prostate cancer earlier in people at genetic risk for disease that forms, grows, or spreads quickly (aggressive). Studying samples of blood, urine, and/or tissue in the laboratory may help doctors further understand the genetics of prostate cancer and help identify ways to detect cancer earlier, thereby improving treatment and methods of early detection in the future.

Conditions

Prostate Carcinoma

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Study Overview

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Study Details

Study overview

This study investigates ways to detect prostate cancer earlier in people at genetic risk for disease that forms, grows, or spreads quickly (aggressive). Studying samples of blood, urine, and/or tissue in the laboratory may help doctors further understand the genetics of prostate cancer and help identify ways to detect cancer earlier, thereby improving treatment and methods of early detection in the future.

PATROL: Prostate Cancer Screening for People AT Genetic Risk FOr Aggressive Disease

Prostate Cancer Screening for People at Genetic Risk for Aggressive Disease, PATROL Study

Condition
Prostate Carcinoma
Intervention / Treatment

-

Contacts and Locations

Duarte

City of Hope, Duarte, California, United States, 91010

San Francisco

University of California, San Francisco, San Francisco, California, United States, 94143

Chicago

Northwestern, Chicago, Illinois, United States, 60611

Boston

Massachusetts General Hospital, Boston, Massachusetts, United States, 02114

Portland

OHSU Knight Cancer Institute, Portland, Oregon, United States, 97239

Philadelphia

University of Pennsylvania/Abramson Cancer Center, Philadelphia, Pennsylvania, United States, 19104

San Antonio

University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States, 78229

Seattle

Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington, United States, 98109

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * People with prostates ≥40 years of age
  • * Documented germline pathogenic variant in known or suspected genes associated with prostate cancer risk.
  • * Prior diagnosis of prostate cancer
  • * Medical contraindication to any of the study procedures (e.g., prostate biopsy)
  • * For all cancer types except non-melanoma skin cancer, any cancer treatment with curative intent within the past 12 months (e.g., surgery, radiation, chemotherapy, immunotherapy)
  • * Prior or concurrent participation in an interventional clinical trial aimed at preventing cancer for people with germline variants associated with increased prostate cancer risk
  • * Unable to provide written informed consent
  • * Unable or unwilling to complete clinical care and study procedures as indicated by the study protocol.

Ages Eligible for Study

40 Years to

Sexes Eligible for Study

MALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Washington,

Heather H. Cheng, MD, PhD, PRINCIPAL_INVESTIGATOR, Fred Hutch/University of Washington Cancer Consortium

Study Record Dates

2030-08-31