Sputum Studies of Anti-Citrullinated Protein Antibodies (ACPA) and Rheumatoid Arthritis (RA) Origins

Description

The study is designed to learn more about the causes of rheumatoid arthritis (RA). People who get RA have elevated protein markers called autoantibodies in their blood years before initial symptoms of arthritis. The goal of this study is to learn more about how autoantibodies in RA might be related to inflammation in the lungs.

Conditions

Rheumatoid Arthritis

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Study Overview

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Study Details

Study overview

The study is designed to learn more about the causes of rheumatoid arthritis (RA). People who get RA have elevated protein markers called autoantibodies in their blood years before initial symptoms of arthritis. The goal of this study is to learn more about how autoantibodies in RA might be related to inflammation in the lungs.

Sputum Studies of Anti-Citrullinated Protein Antibodies (ACPA) and Rheumatoid Arthritis (RA) Origins

Sputum Studies of Anti-Citrullinated Protein Antibodies (ACPA) and Rheumatoid Arthritis (RA) Origins

Condition
Rheumatoid Arthritis
Intervention / Treatment

-

Contacts and Locations

Aurora

University of Colorado Denver (Anschutz Medical Campus), Aurora, Colorado, United States, 80045

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adults between 18 and 100 years;
  • * At-Risk for RA, RA diagnosed, and Healthy Control subjects will be included in the study until recruitment goals are met for each group.
  • 1. No evidence of inflammatory arthritis on clinical examination AND
  • 2. At elevated risk for RA based on familial or serologic risk
  • * Familial risk includes having a first degree relatives (FDRs) with RA
  • * Serologic risk includes asymptomatic serum ACPA positivity
  • 1. No history of RA
  • 2. No FDRs with RA
  • 3. No systemic use of immunosuppressants for autoimmune disease
  • 1. Classified RA by 1987 ACR and/or 2010 ACR/EULAR RA classification criteria (confirmed by medical chart review) OR
  • 2. Diagnosed with RA by a board-certified rheumatologist (confirmed by medical chart review)
  • 1. Currently pregnant or planning to become pregnant during the sample collection period of the study
  • 2. Exacerbation of underlying obstructive lung disease within the past 1 month
  • 3. Known FEV1 \<1 liter
  • 4. Oxygen requirement \>2 liters at rest
  • 5. Participants with health acuity or behavioral health concerns leaving them unable to participate in the current research

Ages Eligible for Study

18 Years to 100 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Colorado, Denver,

Kristen Demoruelle, MD, PhD, PRINCIPAL_INVESTIGATOR, University of Colorado, Denver

Study Record Dates

2025-07-14