RECRUITING

Cortical Priming to Optimize Gait Rehabilitation in Stroke: a Renewal

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Achieving functional ambulation post stroke continues to be a challenge for stroke survivors, clinicians, and researchers. In the effort to enhance outcomes of motor training, cortical priming using brain stimulation has emerged as a promising adjuvant to conventional rehabilitation. This project focuses on the development of a long term gait rehabilitation protocol using brain stimulation to improve walking outcomes in people with stroke. The project will also aim to understand the neural mechanisms that are associated with response to the intervention.

Official Title

Cortical Priming to Optimize Gait Rehabilitation: Renewal

Quick Facts

Study Start:2020-09-01
Study Completion:2025-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04477330

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age greater than 18 years
  2. * First ever monohemispheric stroke \> 3 months since onset
  3. * Residual hemiparetic gait deficits (e.g. abnormal gait pattern)
  4. * Able to walk for 5 minutes at self-paced speed. Handheld assistive device is acceptable.
  5. * Walking speed lesser than 1.2 m/s
  6. * Lower limb Fugl-Meyer Motor score between 15-30
  7. * At least 5 deg of ankle dorsiflexion necessary to perform the ankle-tracking task
  1. * General exclusion criteria
  2. * Severe osteoporosis
  3. * Contracture-limiting range of motion of lower limb
  4. * Score of more than 2 on the Modified Ashworth Scale (indicating increased muscle tone through ankle range of motion)
  5. * Uncontrolled anti-spasticity medications during the study period
  6. * Score less than 6 on the Fugl-Meyer Sensory Assessment Scale for the Lower Limb
  7. * Cardiorespiratory or metabolic diseases (e.g. cardiac arrhythmia, uncontrolled hypertension or diabetes, chronic emphysema)
  8. * Unhealed decubiti, persistent infection
  9. * Significant cognitive or communication impairment (Mini-Mental State Examination (MMSE)\<21), which could impede the understanding of the purpose of procedures of the study or prevent the patient from performing the ankle-tracking task.
  10. * Lesions involving the brainstem and cerebellum
  11. * Failure to pass the graded exercise stress test
  12. * Implanted cardiac pacemaker
  13. * Metal implants in the head or face
  14. * Unexplained, recurring headaches
  15. * History of seizures or epilepsy
  16. * Currently under medication that could increase motor excitability and lower seizure threshold
  17. * Skull abnormalities or fractures
  18. * Concussion within the last 6 months
  19. * Currently pregnant
  20. * Skin hypersensitivity
  21. * History of contact dermatitits
  22. * History of allodynia and/or hyperalgesia
  23. * Any other skin or scalp condition that could be aggravated by tDCS

Contacts and Locations

Study Contact

Sangeetha Madhavan
CONTACT
3123552517
smadhava@uic.edu

Principal Investigator

Sangeetha Madhavan
PRINCIPAL_INVESTIGATOR
University of Illinois at Chicago

Study Locations (Sites)

Physical Therapy
Chicago, Illinois, 60612
United States

Collaborators and Investigators

Sponsor: University of Illinois at Chicago

  • Sangeetha Madhavan, PRINCIPAL_INVESTIGATOR, University of Illinois at Chicago

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-09-01
Study Completion Date2025-12-31

Study Record Updates

Study Start Date2020-09-01
Study Completion Date2025-12-31

Terms related to this study

Keywords Provided by Researchers

  • tDCS
  • Walking

Additional Relevant MeSH Terms

  • Stroke