RECRUITING

PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The Parkinson Progression Marker Initiative (PPMI) is a longitudinal, observational, multi-center natural history study to assess progression of clinical features, digital outcomes, and imaging, biologic and genetic markers of Parkinson's disease (PD) progression in study participants with manifest PD, prodromal PD, and healthy controls. The overall goal of PPMI is to identify markers of disease progression for use in clinical trials of therapies to reduce progression of PD disability.

Official Title

The Parkinson's Progression Markers Initiative (PPMI) Clinical - Establishing a Deeply Phenotyped PD Cohort

Quick Facts

Study Start:2020-07-01
Study Completion:2033-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04477785

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:30 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Cari Rainville, BS
CONTACT
877-525-7764
crainville@indd.org

Principal Investigator

Kenneth L Marek, MD
PRINCIPAL_INVESTIGATOR
Institute for Neurodegenerative Disorders
Caroline Tanner, MD, PhD
PRINCIPAL_INVESTIGATOR
University of California, San Francisco

Study Locations (Sites)

University of Alabama at Birmingham
Birmingham, Alabama, 35294
United States
Barrow Neurological Institute
Phoenix, Arizona, 85013
United States
Mayo Foundation for Medical Education and Research
Scottsdale, Arizona, 85259
United States
Banner Research Institute
Sun City, Arizona, 85351
United States
University of California San Diego
La Jolla, California, 92093-0948
United States
Keck School of Medicine of USC
Los Angeles, California, 90033
United States
University of California, San Francisco
San Francisco, California, 94115
United States
University of Colorado Anschutz Medical Campus
Aurora, Colorado, 80045
United States
Institute For Neurodegenerative Disorders
New Haven, Connecticut, 06510
United States
Parkinson's Disease& Movement Disorder Center of Boca Raton
Boca Raton, Florida, 33486
United States
University of Florida
Gainesville, Florida, 32608
United States
University of South Florida
Tampa, Florida, 33606
United States
Emory University School of Medicine
Atlanta, Georgia, 30329
United States
Northwestern University
Chicago, Illinois, 60611
United States
University of Kansas Medical Center
Kansas City, Kansas, 66160
United States
Johns Hopkins University
Baltimore, Maryland, 21287
United States
Boston University
Boston, Massachusetts, 02118
United States
Massachusetts General Hospital
Boston, Massachusetts, 02446
United States
University of Michigan
Ann Arbor, Michigan, 48109
United States
Cleveland Clinic Lou Ruvo Center for Brain Health
Las Vegas, Nevada, 89106
United States
Beth Israel Medical Center
New York, New York, 10003
United States
NYU Langone Health
New York, New York, 10017
United States
Columbia University Medical Center
New York, New York, 10032
United States
University of Rochester
Rochester, New York, 14620
United States
University of Cincinnati/Cincinnati Children's Hospital
Cincinnati, Ohio, 45219
United States
Cleveland Clinic
Cleveland, Ohio, 44195
United States
Oregon Health &Science University
Portland, Oregon, 97239
United States
University of Pennsylvania
Philadelphia, Pennsylvania, 19107
United States
University of Pittsburgh
Pittsburgh, Pennsylvania, 15213
United States
Baylor College of Medicine
Houston, Texas, 77030
United States
Univ of Washington and VA Puget Sound Health Care System
Seattle, Washington, 98104
United States

Collaborators and Investigators

Sponsor: Michael J. Fox Foundation for Parkinson's Research

  • Kenneth L Marek, MD, PRINCIPAL_INVESTIGATOR, Institute for Neurodegenerative Disorders
  • Caroline Tanner, MD, PhD, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-07-01
Study Completion Date2033-12

Study Record Updates

Study Start Date2020-07-01
Study Completion Date2033-12

Terms related to this study

Keywords Provided by Researchers

  • Parkinson
  • Bio-markers
  • Neurodegenerative disorder
  • Imaging
  • Prodromal
  • Genetics
  • At Risk
  • Loss of Smell

Additional Relevant MeSH Terms

  • Parkinson Disease