Tfh Dysfunction in HIV and Aging

Description

The purpose of this research is to evaluate blood samples from HIV infected and non-HIV infected people to understand how aging and HIV infection affect the immune responses (body defenses against infection) to the flu vaccine.

Conditions

Human Influenza

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Study Overview

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Study Details

Study overview

The purpose of this research is to evaluate blood samples from HIV infected and non-HIV infected people to understand how aging and HIV infection affect the immune responses (body defenses against infection) to the flu vaccine.

Tfh Dysfunction in HIV and Aging

Tfh Dysfunction in HIV and Aging

Condition
Human Influenza
Intervention / Treatment

-

Contacts and Locations

Miami

University of Miami, Miami, Florida, United States, 33136

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. For HIV positive participants:
  • * HIV infection, as documented by any licensed ELISA test kit. Participants on ART as a result of prior HIV documented infection will not be required to provide proof of diagnosis of HIV infection.
  • * Additional criteria for HIV positive
  • 1. on ART for at least 1 year. Occasional viral blips up to 1000 copies/ml also acceptable provided the patients are on continuing treatment,
  • 2. Cluster of differentiation 4 (CD4) count available in the prior 6 months and \>200/mm3
  • 3. Undetectable viral load (\< 40 copies/mL). Blips of \<1000 copies/mL will be allowed.
  • 2. For HIV negative participants:
  • * Documented negative HIV test at the time of study entry, either by any licensed ELISA.
  • 3. For all participants:
  • 1. Individuals age: ≤35 years and ≥65 years.
  • 2. No history of other immunodeficiency disorders
  • 3. Not on steroid or other immunosuppressive/immunomodulators medications.
  • 4. No active malignancies.
  • 5. Agreeable to receive both regular standard (STD-TIV) and high dose (HD-TIV) influenza vaccination.
  • 6. Agreeable to participate in study for a complete course of study full visits including 2 consecutive flu seasons.
  • 7. Able to provide informed consent.
  • 1. Contraindication to receive influenza vaccination.
  • 2. Non-adherence to ART for HIV positive
  • 3. Unable to provide informed consent.
  • 4. Influenza vaccination already given during the current vaccination season.
  • 5. Known drug abuse including cocaine by history

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Miami,

Savita Pahwa, MD, PRINCIPAL_INVESTIGATOR, University of Miami

Study Record Dates

2025-09-30