Neurobiological Mechanisms of Stress in Youth With Chronic Widespread Pain

Description

Chronic widespread pain (CWP) is a common chronic pain condition in youth and often associated with significant pain-related and psychosocial impairment. Understanding the neurobiological mechanisms that may underlie pediatric chronic pain and pain-related impairment can inform future treatments to ameliorate patients' suffering, making it a critical area of empirical investigation.

Conditions

Chronic Widespread Pain, Stress, Psychological, Stress, Physiological

Study Overview

Study Details

Study overview

Chronic widespread pain (CWP) is a common chronic pain condition in youth and often associated with significant pain-related and psychosocial impairment. Understanding the neurobiological mechanisms that may underlie pediatric chronic pain and pain-related impairment can inform future treatments to ameliorate patients' suffering, making it a critical area of empirical investigation.

Neurobiological Mechanisms of Stress in Youth With Chronic Widespread Pain

Neurobiological Mechanisms of Stress in Youth With Chronic Widespread Pain

Condition
Chronic Widespread Pain
Intervention / Treatment

-

Contacts and Locations

Boston

Boston Children's Hospital, Boston, Massachusetts, United States, 02115

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Between ages 11-17 years
  • * Referred to the Boston Children's Hospital Pain Treatment Service for evaluation of a CWP condition with duration \> 3 months
  • * Right-handed
  • * Inability to speak sufficient English to complete questionnaires
  • * Severe cognitive impairment
  • * Prescription steroidal (interference with cortisol measures) or psychotropic medication
  • * Any other chronic pain diagnosis (e.g., migraines, abdominal pain, CRPS)
  • * fMRI contraindications (e.g., dental appliances)

Ages Eligible for Study

11 Years to 17 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Boston Children's Hospital,

Sarah Nelson, PRINCIPAL_INVESTIGATOR, Boston Children's Hospital/Harvard Medical School

Study Record Dates

2024-08-31