RECRUITING

Neurobiological Mechanisms of Stress in Youth With Chronic Widespread Pain

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Chronic widespread pain (CWP) is a common chronic pain condition in youth and often associated with significant pain-related and psychosocial impairment. Understanding the neurobiological mechanisms that may underlie pediatric chronic pain and pain-related impairment can inform future treatments to ameliorate patients' suffering, making it a critical area of empirical investigation.

Official Title

Neurobiological Mechanisms of Stress in Youth With Chronic Widespread Pain

Quick Facts

Study Start:2021-11-04
Study Completion:2024-08-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04488757

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:11 Years to 17 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD
Inclusion CriteriaExclusion Criteria
  1. * Between ages 11-17 years
  2. * Referred to the Boston Children's Hospital Pain Treatment Service for evaluation of a CWP condition with duration \> 3 months
  3. * Right-handed
  1. * Inability to speak sufficient English to complete questionnaires
  2. * Severe cognitive impairment
  3. * Prescription steroidal (interference with cortisol measures) or psychotropic medication
  4. * Any other chronic pain diagnosis (e.g., migraines, abdominal pain, CRPS)
  5. * fMRI contraindications (e.g., dental appliances)

Contacts and Locations

Study Contact

Sarah Nelson, PhD
CONTACT
6173557040
sarah.nelson@childrens.harvard.edu

Principal Investigator

Sarah Nelson
PRINCIPAL_INVESTIGATOR
Boston Children's Hospital/Harvard Medical School

Study Locations (Sites)

Boston Children's Hospital
Boston, Massachusetts, 02115
United States

Collaborators and Investigators

Sponsor: Boston Children's Hospital

  • Sarah Nelson, PRINCIPAL_INVESTIGATOR, Boston Children's Hospital/Harvard Medical School

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-11-04
Study Completion Date2024-08-31

Study Record Updates

Study Start Date2021-11-04
Study Completion Date2024-08-31

Terms related to this study

Keywords Provided by Researchers

  • Chronic Widespread Pain
  • Pediatric Pain
  • Allostatic Load
  • fMRI
  • Mind-Body Interventions

Additional Relevant MeSH Terms

  • Chronic Widespread Pain
  • Stress, Psychological
  • Stress, Physiological