tDCS and Cognitive Training for Mild Cognitive Impairment and Alzheimer's Dementia

Description

There are currently no disease-modifying treatments for cognitive and behavioral symptoms associated with early clinical Alzheimer's disease (AD), and only minimally effective symptomatic treatments are available. In this application, we propose a transcranial direct current stimulation (tDCS) augmented executive functioning training intervention. This intervention will target cognition and brain circuits that are impaired in patients with mild cognitive impairment (MCI) and early AD. The goal is to improve cognitive performance and functional outcomes in patients with MCI and early AD.

Conditions

Alzheimer Disease, Mild Cognitive Impairment

Talk to us

Study Overview

On this page

Study Details

Study overview

There are currently no disease-modifying treatments for cognitive and behavioral symptoms associated with early clinical Alzheimer's disease (AD), and only minimally effective symptomatic treatments are available. In this application, we propose a transcranial direct current stimulation (tDCS) augmented executive functioning training intervention. This intervention will target cognition and brain circuits that are impaired in patients with mild cognitive impairment (MCI) and early AD. The goal is to improve cognitive performance and functional outcomes in patients with MCI and early AD.

Combined tDCS and Cognitive Training for Mild Cognitive Impairment (MCI) and Early Clinical Alzheimer's Type Dementia (CATD)

tDCS and Cognitive Training for Mild Cognitive Impairment and Alzheimer's Dementia

Condition
Alzheimer Disease
Intervention / Treatment

-

Contacts and Locations

Minneapolis

Minneapolis VA Health Care System, Minneapolis, Minnesota, United States, 55417

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * are a Veteran receiving services from the MVAHCS GRECC clinic
  • * have a clinical diagnosis of AD, MCI, or Mild Neurocognitive Disorder presenting as early AD type (predominantly amnestic and dysexecutive)
  • * are age 60 or older
  • * are stable on any medications for at least 1 month at the baseline visit
  • * demonstrate capacity to provide informed consent
  • * have WiFi access in their home
  • * have a family member or friend willing to serve as a care partner (care partner needs to have a minimum of 10 hours per week that they see the participant, if they don't live with them).
  • * any significant medical disorder based on the Principal Investigator's judgment that would impact risk
  • * other psychiatric or neurological conditions that impact cognition
  • * metallic cranial plates/screws or implanted devices above the clavicle
  • * eczema on scalp or other scalp lesions or skin disorders that may become irritated by stimulation

Ages Eligible for Study

60 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Minneapolis Veterans Affairs Medical Center,

John R McCarten, MD, PRINCIPAL_INVESTIGATOR, Minneapolis Veterans Affairs Medical Center

Study Record Dates

2024-09