Childhood Cancer Predisposition Study (CCPS)

Description

The Childhood Cancer Predisposition Study (CCPS) is a multi-center, longitudinal, observational study that will collect clinical and biological data and specimens from children with a cancer predisposition syndromes (CPS) and their relatives. The central hypothesis is that studying individuals at high risk for childhood cancer creates a unique opportunity for improving the understanding of carcinogenesis, tumor surveillance, early detection, and cancer prevention, which will collectively contribute to improving care and outcomes for pediatric patients with cancer and those with cancer predisposition syndromes (CPS).

Conditions

Pediatric Cancer

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Study Overview

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Study Details

Study overview

The Childhood Cancer Predisposition Study (CCPS) is a multi-center, longitudinal, observational study that will collect clinical and biological data and specimens from children with a cancer predisposition syndromes (CPS) and their relatives. The central hypothesis is that studying individuals at high risk for childhood cancer creates a unique opportunity for improving the understanding of carcinogenesis, tumor surveillance, early detection, and cancer prevention, which will collectively contribute to improving care and outcomes for pediatric patients with cancer and those with cancer predisposition syndromes (CPS).

Childhood Cancer Predisposition Study (CCPS)

Childhood Cancer Predisposition Study (CCPS)

Condition
Pediatric Cancer
Intervention / Treatment

-

Contacts and Locations

Atlanta

Children's Healthcare of Atlanta (CHOA), Atlanta, Georgia, United States, 30322

Boston

Dana Farber Cancer Institute, Boston, Massachusetts, United States, 02215

Philadelphia

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States, 19104

Memphis

St. Jude Children's Research Hospital, Memphis, Tennessee, United States, 38105-3678

Houston

Baylor College of Medicine, Houston, Texas, United States, 77030

Salt Lake City

Primary Children's Hospital, Salt Lake City, Utah, United States, 84113

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Be less than 21 years of age at the time of enrollment
  • 2. Have a diagnosis of a specific CPS, whether they have had cancer or not
  • * Based on clinical laboratory testing demonstrating a Pathogenic or Likely Pathogenic germline variant and/or
  • * Based on well-established clinical diagnostic criteria and/or
  • * Based on high clinical suspicion of a specific CPS with clinical laboratory testing demonstrating a variant of uncertain significance (VUS)
  • 1. Be the biologic parent of a Primary Subject and
  • 2. Carry a diagnosis (or obligate diagnosis) of the familial CPS
  • 1. Be the biologic sibling of a Primary Subject and
  • 2. Carry a diagnosis (or obligate diagnosis) of the familial CPS
  • 1. Be the biologic parent or sibling of a Primary Subject and
  • 2. Not carry a diagnosis (or obligate diagnosis) of the familial CPS
  • 1. Carry a diagnosis of (or obligate diagnosis of) the familial CPS. Documentation is requested but not required.
  • * Individuals with a strong personal or family history of cancer without a genetic or clinical diagnosis of a specific CPS are not eligible for enrollment.

Ages Eligible for Study

to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Emory University,

Christopher Porter, MD, PRINCIPAL_INVESTIGATOR, Emory University

Anita Villani, MD, PRINCIPAL_INVESTIGATOR, The Hospital for Sick Children

Study Record Dates

2030-10