Vaginal Cleansing With Chlorhexidine Gluconate in Women With Preterm Pre-labor Rupture of Membranes

Description

Randomized controlled trial studying the use of vaginal cleansing with chlorhexidine gluconate for pregnant women with PPROM (preterm pre labor rupture of membranes). The primary outcome will be pregnancy latency. Secondary outcomes will include various maternal and neonatal outcomes, and inflammatory markers from maternal blood, amniotic fluid, fetal cord blood and placental analysis.

Conditions

Preterm Premature Rupture of Membrane

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Study Overview

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Study Details

Study overview

Randomized controlled trial studying the use of vaginal cleansing with chlorhexidine gluconate for pregnant women with PPROM (preterm pre labor rupture of membranes). The primary outcome will be pregnancy latency. Secondary outcomes will include various maternal and neonatal outcomes, and inflammatory markers from maternal blood, amniotic fluid, fetal cord blood and placental analysis.

Vaginal Cleansing With Chlorhexidine Gluconate in Women With Preterm Pre-labor Rupture of Membranes in Order to Prolong Pregnancy Latency and Reduce Intraamniotic Inflammation

Vaginal Cleansing With Chlorhexidine Gluconate in Women With Preterm Pre-labor Rupture of Membranes

Condition
Preterm Premature Rupture of Membrane
Intervention / Treatment

-

Contacts and Locations

Albany

Albany Medical Center, Albany, New York, United States, 12208

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Pregnant patients at our institution with PPROM diagnosed between 20 - 33 weeks
  • * active preterm labor or imminent delivery expected at the time of PPROM diagnosis
  • * maternal sepsis or chorioamnionitis
  • * any contraindications to expectant management (fetal distress, placental abruption with maternal hemodynamic instability or fetal distress cord prolapse)
  • * preeclampsia
  • * intrauterine growth restriction (IUGR)
  • * no antibiotics or steroids given within 7 days prior to the time of enrollment
  • * multiple gestation
  • * placenta previa
  • * fetal part visualized at initial exam
  • * visual cervical dilation at initial exam

Ages Eligible for Study

18 Years to 50 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Albany Medical College,

Study Record Dates

2024-12-31