Longitudinal Neuroimaging in Sturge-Weber Syndrome

Description

In this project the accuracy of a novel, rapid magnetic resonance imaging (MRI) approach to detect brain abnormalities in patients with Sturge-Weber syndrome (SWS) will be tested; this new imaging approach, that can create multiple types of MR images in about 5 minutes, without contrast administration (and sedation even in young children), can be also readily applied in other pediatric brain disorders in the future. The investigators will also study how advanced MRI, including susceptibility-weighted and diffusion tensor imaging can detect detailed signs of brain vascular and neuronal reorganization that helps improve neurological and cognitive outcome of children and young adults with SWS, who could benefit from targeted interventions in the future to minimize neurocognitive deficits in affected patients. All enrolled subjects will undergo advanced brain MRI and neurocognitive evaluation to achieve these goals.

Conditions

Sturge-Weber Syndrome

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Study Overview

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Study Details

Study overview

In this project the accuracy of a novel, rapid magnetic resonance imaging (MRI) approach to detect brain abnormalities in patients with Sturge-Weber syndrome (SWS) will be tested; this new imaging approach, that can create multiple types of MR images in about 5 minutes, without contrast administration (and sedation even in young children), can be also readily applied in other pediatric brain disorders in the future. The investigators will also study how advanced MRI, including susceptibility-weighted and diffusion tensor imaging can detect detailed signs of brain vascular and neuronal reorganization that helps improve neurological and cognitive outcome of children and young adults with SWS, who could benefit from targeted interventions in the future to minimize neurocognitive deficits in affected patients. All enrolled subjects will undergo advanced brain MRI and neurocognitive evaluation to achieve these goals.

Longitudinal Neuroimaging in Sturge-Weber Syndrome

Longitudinal Neuroimaging in Sturge-Weber Syndrome

Condition
Sturge-Weber Syndrome
Intervention / Treatment

-

Contacts and Locations

Detroit

Wayne State University / Children's Hospital of Michigan, Detroit, Michigan, United States, 48201

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Subjects with Sturge-Weber syndrome (SWS):
  • 1. Age 3 months - 30 years;
  • 2. Presence of a facial port-wine birthmark (PWB) indicating a risk for SWS and/or evidence of SWS brain involvement based on the presence of one or more intracranial SWS brain abnormalities from previous clinical imaging (MRI or computed tomography) scan(s) with or without a facial PWB. SWS brain abnormalities can include both brain vascular and/or parenchymal abnormalities (including atrophy, calcification, etc.);
  • 3. In children who will undergo formal neuropsychology testing including detailed language testing (age 3 years and above): proficiency of English language.
  • 2. Healthy control subjects:
  • 1. Age 3 years - 30 years;
  • 2. No history of neurological or psychiatric disorder
  • 1. Metal in the head or mouth that would preclude safe, artifact-free MRI scanning; or any other metal or electronic device contraindicated for MRI scanning.
  • 2. History of severe claustrophobia, precluding staying still in the scanner for up to 30 minutes.
  • 3. Pregnancy (pregnant women will be scheduled for the study after delivery).

Ages Eligible for Study

3 Months to 30 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Wayne State University,

Study Record Dates

2025-02-28