RECRUITING

Longitudinal Neuroimaging in Sturge-Weber Syndrome

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

In this project the accuracy of a novel, rapid magnetic resonance imaging (MRI) approach to detect brain abnormalities in patients with Sturge-Weber syndrome (SWS) will be tested; this new imaging approach, that can create multiple types of MR images in about 5 minutes, without contrast administration (and sedation even in young children), can be also readily applied in other pediatric brain disorders in the future. The investigators will also study how advanced MRI, including susceptibility-weighted and diffusion tensor imaging can detect detailed signs of brain vascular and neuronal reorganization that helps improve neurological and cognitive outcome of children and young adults with SWS, who could benefit from targeted interventions in the future to minimize neurocognitive deficits in affected patients. All enrolled subjects will undergo advanced brain MRI and neurocognitive evaluation to achieve these goals.

Official Title

Longitudinal Neuroimaging in Sturge-Weber Syndrome

Quick Facts

Study Start:2020-03-01
Study Completion:2025-02-28
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04517565

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:3 Months to 30 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD, ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Subjects with Sturge-Weber syndrome (SWS):
  2. 1. Age 3 months - 30 years;
  3. 2. Presence of a facial port-wine birthmark (PWB) indicating a risk for SWS and/or evidence of SWS brain involvement based on the presence of one or more intracranial SWS brain abnormalities from previous clinical imaging (MRI or computed tomography) scan(s) with or without a facial PWB. SWS brain abnormalities can include both brain vascular and/or parenchymal abnormalities (including atrophy, calcification, etc.);
  4. 3. In children who will undergo formal neuropsychology testing including detailed language testing (age 3 years and above): proficiency of English language.
  5. 2. Healthy control subjects:
  6. 1. Age 3 years - 30 years;
  7. 2. No history of neurological or psychiatric disorder
  1. 1. Metal in the head or mouth that would preclude safe, artifact-free MRI scanning; or any other metal or electronic device contraindicated for MRI scanning.
  2. 2. History of severe claustrophobia, precluding staying still in the scanner for up to 30 minutes.
  3. 3. Pregnancy (pregnant women will be scheduled for the study after delivery).

Contacts and Locations

Study Contact

Csaba Juhasz, MD, PhD
CONTACT
313-966-5136
csaba.juhasz@wayne.edu
Aimee Luat, MD
CONTACT
313-832-9620
aluat@dmc.org

Study Locations (Sites)

Wayne State University / Children's Hospital of Michigan
Detroit, Michigan, 48201
United States

Collaborators and Investigators

Sponsor: Wayne State University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-03-01
Study Completion Date2025-02-28

Study Record Updates

Study Start Date2020-03-01
Study Completion Date2025-02-28

Terms related to this study

Additional Relevant MeSH Terms

  • Sturge-Weber Syndrome