RECRUITING

CT-Based Changes in Bone and Marrow Among Patients on Oral Steroids

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Conditions

AsthmaBone Density, LowOral Steroid-Dependent Asthma (Disorder)GlucocorticoidCorticosteroid

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to assess the feasibility of emerging CT-based tools to measure changes in central and peripheral bone density, micro-structure, and marrow adipose tissue (MAT) among patients treated with oral steroids.

Official Title

CT-Based Changes in Bone and Marrow Among Patients on Oral Steroids

Quick Facts

Study Start:2020-12-01
Study Completion:2025-09-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04518722

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:25 Years to 45 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Inclusion (all subjects):
  2. * Diagnosis of severe, persistent asthma (defined as using both a long-acting beta-agonist AND a high-dose inhaled steroid)
  3. * Age 25-45
  4. * Inclusion (oral steroid group):
  5. * Chronic treatment with oral steroids for at least 45 days but less than 1 year
  1. * Exclusion (all subjects):
  2. * Pregnant or breastfeeding
  3. * History of any cancer, excluding non-melanoma skin cancer
  4. * Currently receiving dialysis
  5. * History of any lower extremity fracture
  6. * Hip or knee replacement
  7. * Non-ambulatory
  8. * Greater than 10 pack-year smoking history
  9. * BMI \> 50
  10. * Age \< 25 or \> 45
  11. * Current or past use of FDA-approved medication for osteoporosis:

Contacts and Locations

Study Contact

Taylor M Haynes, MS
CONTACT
319-356-1785
taylor-haynes@uiowa.edu
Punam K Saha, PhD
CONTACT
319-335-5959
punam-saha@uiowa.edu

Principal Investigator

Punam K Saha, PhD
PRINCIPAL_INVESTIGATOR
University of Iowa

Study Locations (Sites)

University of Iowa
Iowa City, Iowa, 52242
United States

Collaborators and Investigators

Sponsor: University of Iowa

  • Punam K Saha, PhD, PRINCIPAL_INVESTIGATOR, University of Iowa

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-12-01
Study Completion Date2025-09-01

Study Record Updates

Study Start Date2020-12-01
Study Completion Date2025-09-01

Terms related to this study

Keywords Provided by Researchers

  • Glucocorticoid
  • Corticosteroid

Additional Relevant MeSH Terms

  • Asthma
  • Bone Density, Low
  • Oral Steroid-Dependent Asthma (Disorder)