CT-Based Changes in Bone and Marrow Among Patients on Oral Steroids

Description

The goal of this study is to assess the feasibility of emerging CT-based tools to measure changes in central and peripheral bone density, micro-structure, and marrow adipose tissue (MAT) among patients treated with oral steroids.

Conditions

Asthma, Bone Density, Low, Oral Steroid-Dependent Asthma (Disorder)

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Study Overview

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Study Details

Study overview

The goal of this study is to assess the feasibility of emerging CT-based tools to measure changes in central and peripheral bone density, micro-structure, and marrow adipose tissue (MAT) among patients treated with oral steroids.

CT-Based Changes in Bone and Marrow Among Patients on Oral Steroids

CT-Based Changes in Bone and Marrow Among Patients on Oral Steroids

Condition
Asthma
Intervention / Treatment

-

Contacts and Locations

Iowa City

University of Iowa, Iowa City, Iowa, United States, 52242

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Inclusion (all subjects):
  • * Diagnosis of severe, persistent asthma (defined as using both a long-acting beta-agonist AND a high-dose inhaled steroid)
  • * Age 25-45
  • * Inclusion (oral steroid group):
  • * Chronic treatment with oral steroids for at least 45 days but less than 1 year
  • * Exclusion (all subjects):
  • * Pregnant or breastfeeding
  • * History of any cancer, excluding non-melanoma skin cancer
  • * Currently receiving dialysis
  • * History of any lower extremity fracture
  • * Hip or knee replacement
  • * Non-ambulatory
  • * Greater than 10 pack-year smoking history
  • * BMI \> 50
  • * Age \< 25 or \> 45
  • * Current or past use of FDA-approved medication for osteoporosis:

Ages Eligible for Study

25 Years to 45 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Iowa,

Punam K Saha, PhD, PRINCIPAL_INVESTIGATOR, University of Iowa

Study Record Dates

2025-09-01