Exercise-stimulated Muscle Glucose Uptake in Upper Body Obesity

Description

The purpose of this study is to provide the first integrated examination of the interaction between muscle insulin action and exercise-stimulated muscle glucose uptake in obesity from the whole body to the cellular/molecular level.

Conditions

Upper Body Obesity

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Study Overview

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Study Details

Study overview

The purpose of this study is to provide the first integrated examination of the interaction between muscle insulin action and exercise-stimulated muscle glucose uptake in obesity from the whole body to the cellular/molecular level.

Exercise-stimulated Muscle Glucose Uptake in Upper Body Obesity

Exercise-stimulated Muscle Glucose Uptake in Upper Body Obesity

Condition
Upper Body Obesity
Intervention / Treatment

-

Contacts and Locations

Rochester

Mayo Clinic in Rochester, Rochester, Minnesota, United States, 55905

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Sedentary, normal weight, premenopausal women.
  • * Sedentary, age-matched normal weight men.
  • * Weight stable for two (2) months prior to study.
  • * Willing to provide written, informed consent.
  • * For the exercise studies of leg glucose uptake - "insulin resistant" group:
  • * Upper body obese (UBO) premenopausal women.
  • * Age-matched upper body obese (UBO) men.
  • * Weight stable for two (2) months prior to study.
  • * Willing to provide written, informed consent.
  • * Age \< 18 or \> 55 years (premenopausal women and age-matched men).
  • * Use of glucose-lowering agents.
  • * For female subjects: positive pregnancy test at the time of enrollment or study
  • * History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
  • * Active systemic illness or malignancy.
  • * Symptomatic macrovascular or microvascular disease.

Ages Eligible for Study

18 Years to 55 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Mayo Clinic,

Michael D Jensen, MD, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

2025-07