ACTIVE_NOT_RECRUITING

Exercise-stimulated Muscle Glucose Uptake in Upper Body Obesity

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to provide the first integrated examination of the interaction between muscle insulin action and exercise-stimulated muscle glucose uptake in obesity from the whole body to the cellular/molecular level.

Official Title

Exercise-stimulated Muscle Glucose Uptake in Upper Body Obesity

Quick Facts

Study Start:2020-11-06

Study Completion:2025-07-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:ACTIVE_NOT_RECRUITING

Study ID

NCT04532814

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 55 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT

Inclusion Criteria	Exclusion Criteria
* Sedentary, normal weight, premenopausal women. * Sedentary, age-matched normal weight men. * Weight stable for two (2) months prior to study. * Willing to provide written, informed consent. * For the exercise studies of leg glucose uptake - "insulin resistant" group: * Upper body obese (UBO) premenopausal women. * Age-matched upper body obese (UBO) men. * Weight stable for two (2) months prior to study. * Willing to provide written, informed consent.	* Age \< 18 or \> 55 years (premenopausal women and age-matched men). * Use of glucose-lowering agents. * For female subjects: positive pregnancy test at the time of enrollment or study * History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy. * Active systemic illness or malignancy. * Symptomatic macrovascular or microvascular disease.

Inclusion Criteria

Exclusion Criteria

* Sedentary, normal weight, premenopausal women.
* Sedentary, age-matched normal weight men.
* Weight stable for two (2) months prior to study.
* Willing to provide written, informed consent.
* For the exercise studies of leg glucose uptake - "insulin resistant" group:
* Upper body obese (UBO) premenopausal women.
* Age-matched upper body obese (UBO) men.
* Weight stable for two (2) months prior to study.
* Willing to provide written, informed consent.

* Age \< 18 or \> 55 years (premenopausal women and age-matched men).
* Use of glucose-lowering agents.
* For female subjects: positive pregnancy test at the time of enrollment or study
* History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
* Active systemic illness or malignancy.
* Symptomatic macrovascular or microvascular disease.

Contacts and Locations

Principal Investigator

Michael D Jensen, MD

PRINCIPAL_INVESTIGATOR

Mayo Clinic

Study Locations (Sites)

Mayo Clinic in Rochester

Rochester, Minnesota, 55905

United States

Collaborators and Investigators

Sponsor: Mayo Clinic

Michael D Jensen, MD, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-11-06

Study Completion Date2025-07-31

Study Record Updates

Study Start Date2020-11-06

Study Completion Date2025-07-31

Terms related to this study

Additional Relevant MeSH Terms

Upper Body Obesity