ACTIVE_NOT_RECRUITING

Individualized Targeting and Neuromodulation of Late-Life Depression

Conditions

Major Depressive Disorder depression geriatric rTMS fMRI neuronavigation

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

An open-label, single-arm, clinical research study about how to make transcranial magnetic stimulation (TMS), an FDA-approved treatment, more effective for patients with late-life depression using fMRI.

Official Title

Individualized Targeting and Neuromodulation of Late-Life Depression

Quick Facts

Study Start:2024-10-01

Study Completion:2026-07-01

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:ACTIVE_NOT_RECRUITING

Study ID

NCT04543773

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:60 Years to 79 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
1. Participant must be at least 60 years of age (all genders, races, and ethnicities), and less than or equal to 79 years of age. 2. Participant must have a diagnosis of major depressive disorder without psychosis for the past 6 months, as diagnosed by a board-certified psychiatrist 3. Must show evidence of being in a current major depressive episode, as indicated by score on QIDS-C of 10 or higher. 4. Participant must not have any conditions listed in the exclusion criteria 5. Participant must be fluent in English	1. Current diagnosis of bipolar disorder, schizophrenia, schizoaffective disorder, or any other psychotic disorder 2. Substance use disorder, abuse or dependence, with active use within the last 3 months 3. Legal or mental incompetency, or inability to consent to study 4. Unstable medical illness, or hospitalization within 3 weeks of study entry 5. Current diagnosis of a neurological disorder or neurocognitive disorder 6. Prior neurosurgical procedure 7. History of seizure 8. History of ECT treatment within the past three months 9. History of any previous TMS treatment 10. Any contraindication to obtaining magnetic resonance imaging safely 11. Pregnant women 12. Inability to complete the protocol, namely, inability to independently attend all study visits and TMS sessions on time.

Inclusion Criteria

Exclusion Criteria

1. Participant must be at least 60 years of age (all genders, races, and ethnicities), and less than or equal to 79 years of age.
2. Participant must have a diagnosis of major depressive disorder without psychosis for the past 6 months, as diagnosed by a board-certified psychiatrist
3. Must show evidence of being in a current major depressive episode, as indicated by score on QIDS-C of 10 or higher.
4. Participant must not have any conditions listed in the exclusion criteria
5. Participant must be fluent in English

1. Current diagnosis of bipolar disorder, schizophrenia, schizoaffective disorder, or any other psychotic disorder
2. Substance use disorder, abuse or dependence, with active use within the last 3 months
3. Legal or mental incompetency, or inability to consent to study
4. Unstable medical illness, or hospitalization within 3 weeks of study entry
5. Current diagnosis of a neurological disorder or neurocognitive disorder
6. Prior neurosurgical procedure
7. History of seizure
8. History of ECT treatment within the past three months
9. History of any previous TMS treatment
10. Any contraindication to obtaining magnetic resonance imaging safely
11. Pregnant women
12. Inability to complete the protocol, namely, inability to independently attend all study visits and TMS sessions on time.

Contacts and Locations

Study Locations (Sites)

University of New Mexico HSC

Albuquerque, New Mexico, 87106

United States

Collaborators and Investigators

Sponsor: University of New Mexico

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-10-01

Study Completion Date2026-07-01

Study Record Updates

Study Start Date2024-10-01

Study Completion Date2026-07-01

Terms related to this study

Keywords Provided by Researchers

depression
geriatric
rTMS
fMRI
neuronavigation

Additional Relevant MeSH Terms

Major Depressive Disorder