Individualized Targeting and Neuromodulation of Late-Life Depression

Description

An open-label, single-arm, clinical research study about how to make transcranial magnetic stimulation (TMS), an FDA-approved treatment, more effective for patients with late-life depression using fMRI.

Conditions

Major Depressive Disorder

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Study Overview

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Study Details

Study overview

An open-label, single-arm, clinical research study about how to make transcranial magnetic stimulation (TMS), an FDA-approved treatment, more effective for patients with late-life depression using fMRI.

Individualized Targeting and Neuromodulation of Late-Life Depression

Individualized Targeting and Neuromodulation of Late-Life Depression

Condition
Major Depressive Disorder
Intervention / Treatment

-

Contacts and Locations

Albuquerque

University of New Mexico HSC, Albuquerque, New Mexico, United States, 87106

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Participant must be at least 60 years of age (all genders, races, and ethnicities), and less than or equal to 79 years of age.
  • 2. Participant must have a diagnosis of major depressive disorder without psychosis for the past 6 months, as diagnosed by a board-certified psychiatrist
  • 3. Must show evidence of being in a current major depressive episode, as indicated by score on QIDS-C of 10 or higher.
  • 4. Participant must not have any conditions listed in the exclusion criteria
  • 5. Participant must be fluent in English
  • 1. Current diagnosis of bipolar disorder, schizophrenia, schizoaffective disorder, or any other psychotic disorder
  • 2. Substance use disorder, abuse or dependence, with active use within the last 3 months
  • 3. Legal or mental incompetency, or inability to consent to study
  • 4. Unstable medical illness, or hospitalization within 3 weeks of study entry
  • 5. Current diagnosis of a neurological disorder or neurocognitive disorder
  • 6. Prior neurosurgical procedure
  • 7. History of seizure
  • 8. History of ECT treatment within the past three months
  • 9. History of any previous TMS treatment
  • 10. Any contraindication to obtaining magnetic resonance imaging safely
  • 11. Pregnant women
  • 12. Inability to complete the protocol, namely, inability to independently attend all study visits and TMS sessions on time.

Ages Eligible for Study

60 Years to 79 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of New Mexico,

Study Record Dates

2025-12-31