Network-guided TMS in Early Alzheimer's Disease

Description

The proposed research will test a novel network-based neurostimulation approach using MRI-derived measures of brain connectivity to establish target sites for neurostimulation and test for the enhancement of memory function beyond a sham stimulation condition. This will be tested in cohort of MCI adults using network-based transcranial magnetic stimulation (TMS) to assess for behavioral improvement due to the controlled intervention. This study will provide important evidence towards the efficacy of neuromodulatory treatments for memory decline and will accelerate the discovery of potent non-invasive treatments to remediate cognitive decline in cognitively impaired older adults.

Conditions

Mild Cognitive Impairment

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Study Overview

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Study Details

Study overview

The proposed research will test a novel network-based neurostimulation approach using MRI-derived measures of brain connectivity to establish target sites for neurostimulation and test for the enhancement of memory function beyond a sham stimulation condition. This will be tested in cohort of MCI adults using network-based transcranial magnetic stimulation (TMS) to assess for behavioral improvement due to the controlled intervention. This study will provide important evidence towards the efficacy of neuromodulatory treatments for memory decline and will accelerate the discovery of potent non-invasive treatments to remediate cognitive decline in cognitively impaired older adults.

Using Network-guided TMS to Ameliorate Memory Deficits in Early Alzheimer's Disease

Network-guided TMS in Early Alzheimer's Disease

Condition
Mild Cognitive Impairment
Intervention / Treatment

-

Contacts and Locations

Durham

Duke University Medical Center, Durham, North Carolina, United States, 27710

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Elderly: age between 55-80
  • * English speaking
  • * Willing to provide consent
  • * Signed HIPAA authorization
  • * Use of effective method of birth control for women of childbearing capacity
  • * Clinical Consensus for MCI
  • * History of any Axis I DSM-IV disorder
  • * Current or past history of substance abuse or dependence (excluding nicotine)
  • * Women who are pregnant or breast feeding
  • * Intracranial implants (e.g. aneurysms clips, shunts, stimulators, cochlear implants, or electrodes), cardiac pacemakers, or vagus Nerve stimulation device
  • * Increased risk of seizure for any reason, including prior diagnosis of epilepsy, seizure disorder, increased intracranial pressure, or history of significant head trauma with loss of consciousness for ≥ 30 minutes.
  • * Neurological disorder including, but not limited to: space occupying brain lesion; any history of seizures, history of cerebrovascular accident; fainting, cerebral aneurysm,
  • * Dementia, Hungtington chorea; Multiple Sclerosis.
  • * Current use of medications known to lower the seizure threshold and/or affect working memory
  • * Current or past history of substance abuse or dependence (excluding nicotine)
  • * Women who are pregnant or breast feeding

Ages Eligible for Study

55 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Duke University,

Simon W Davis, PhD, PRINCIPAL_INVESTIGATOR, Duke University

Study Record Dates

2025-06-30