Exercise Therapy and Radiation Therapy (EXERT) for Metastatic Prostate Cancer

Description

This study is being done to determine if patients receiving personalized exercise therapy (versus those who do not receive personalized exercise therapy) have improved quality of life and physical functioning after completing their radiation therapy. Second, the study is being done to find if the quality of life changes during therapy correlate with measurements of inflammation in the blood. Third, the study is being done to see if adding exercise therapy to radiation therapy will improve survival.

Conditions

Metastatic Prostate Cancer

Study Overview

Study Details

Study overview

This study is being done to determine if patients receiving personalized exercise therapy (versus those who do not receive personalized exercise therapy) have improved quality of life and physical functioning after completing their radiation therapy. Second, the study is being done to find if the quality of life changes during therapy correlate with measurements of inflammation in the blood. Third, the study is being done to see if adding exercise therapy to radiation therapy will improve survival.

Exercise Therapy and Radiation Therapy (EXERT) for Metastatic Prostate Cancer

Exercise Therapy and Radiation Therapy (EXERT) for Metastatic Prostate Cancer

Condition
Metastatic Prostate Cancer
Intervention / Treatment

-

Contacts and Locations

Cleveland

University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center, Cleveland, Ohio, United States, 44106

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Subjects must have metastatic disease consistent with prostate cancer
  • * Males ≥18 years of age receiving first palliative course of RT for metastatic prostate cancer
  • * Patient receiving radiation dose of 20 Gray (Gy) in 5 fractions or stereotactic body radiation therapy (SBRT)
  • * Patient may have received prior hormone therapy. Prior or current use of chemotherapy agents is allowed, but not necessary.
  • * Fluent in written and spoken English
  • * Must be able to provide and understand informed consent
  • * Must have an ECOG Performance Status (PS) of ≤ 3
  • * Primary attending radiation oncologist approval
  • * Performing \> 90 minutes/week of exercise therapy prior at time of enrollment
  • * Evidence in the medical record of an absolute contraindication for exercise
  • * Cardiac

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

MALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Case Comprehensive Cancer Center,

Nicholas Zaorsky, MD, PRINCIPAL_INVESTIGATOR, University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center

Study Record Dates

2026-01-01