RECRUITING

Examining Effects of Tysabri on Cognitive Fatigue Using fMRI

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this research study is to investigate the effectiveness of Tysabri on cognitive fatigue in persons with Relapsing-Remitting Multiple Sclerosis (RRMS). Cognitive fatigue is the kind of fatigue that occurs after intense mental concentration as after a session of problem solving.

Official Title

Biomarker for Cognitive Fatigue Using Functional Imaging in Multiple Sclerosis

Quick Facts

Study Start:2021-03-19
Study Completion:2024-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04565431

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 64 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age between 18-64
  2. * Diagnosed with Relapsing-Remitting Multiple Sclerosis or a healthy volunteer
  3. * If diagnosed with MS: has been newly prescribed Tysabri, but has not yet started taking the medication
  4. * Can read and speak English fluently
  1. * History of head injury, stroke, seizures, or any other significant neurological event other than MS
  2. * Flare up of MS symptoms within the past month
  3. * History of significant psychiatric illness (for example, bipolar disorder, schizophrenia, or psychosis) or a current diagnosis of Major Depressive Disorder
  4. * Pacemaker or other implanted electrical device, brain stimulator, aneurysm clip (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and internal hearing aids \[cochlear implants\]), permanent eyeliner, implanted delivery pumps, or shrapnel fragments
  5. * Left-handed.
  6. * Not able to have an MRI

Contacts and Locations

Study Contact

Nancy Moore, M.A.
CONTACT
19733248450
nbmoore@kesslerfoundation.org
Angela Smith, M.A.
CONTACT
19733248448
asmith@kesslerfoundation.org

Principal Investigator

John DeLuca, Ph.D.
PRINCIPAL_INVESTIGATOR
Kessler Foundation

Study Locations (Sites)

Kessler Foundation
West Orange, New Jersey, 07052
United States

Collaborators and Investigators

Sponsor: Kessler Foundation

  • John DeLuca, Ph.D., PRINCIPAL_INVESTIGATOR, Kessler Foundation

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-03-19
Study Completion Date2024-12

Study Record Updates

Study Start Date2021-03-19
Study Completion Date2024-12

Terms related to this study

Keywords Provided by Researchers

  • Multiple Sclerosis
  • Cognitive Fatigue

Additional Relevant MeSH Terms

  • Multiple Sclerosis, Relapsing-Remitting