Sildenafil for Treatment of Urinary Incontinence in Patients With Spinal Cord Injuries

Eligibility Criteria

• * Adults with spinal cord injury (SCI), 18-75 years of age, at the time of consent
• * Have urinary incontinence (UI), with at least 3 leakage episodes/week
• * Have urodynamics assessment on file with their provider in past 3 years. If no historical data on file, subject may complete prior to study visit 1.
• * Willing and able to comply with study procedures
• * Willing and able to provide written informed consent
• * In phone prescreen, delighted or pleased with current quality of life due to urinary symptoms.
• * Indwelling catheter
• * History of greater than 4 urinary tract infections per year
• * Multiple sclerosis
• * Significant heart, liver, kidney, pulmonary, blood, autoimmune or peripheral vascular disease
• * Systolic blood pressure \<90 or \>170, diastolic blood pressure \<50 or \>110 after repeated evaluation with proper cuff. This range is the acceptable range stated in the prescribing information for sildenafil (\>90/50 and \<170/110)
• * Active cancer
• * HIV, Hepatitis B, or Hepatitis C
• * Use of systemic nitrates, anabolic steroids, corticosteroids, or long acting PDE5 inhibitors in the past 1 month
• * Use of short acting PDE5 inhibitors in the past 1 week
• * Use of alpha blockers, anticholinergic agents, bethanechol, or other UI treatment within the past 2 weeks ( 3 weeks for long acting muscarinic receptor antagonists)
• * Known allergic reaction to any agent under investigation or required by the protocol
• * Females who are pregnant or lactating
• * Atonic bladder or high detrusor and high pelvic floor muscle pressure based on previous cystometrogram (CMG) (on file with their provider) that would place subjects at risk for kidney injury
• * Any medical condition that, in the opinion of the investigator, would place the subject at increased risk for participation