Sleep Spindles and Memory in Rolandic Epilepsy

Description

The investigators are recruiting children with Rolandic epilepsy and children without epilepsy (aged 4 years old and above) for a non-invasive brain imaging study using Magnetic Resonance Imaging (MRI), Magnetoencephalography/Electroencephalography (MEG/EEG), and experimental tasks. The investigators hope to determine the brain circuits and brain rhythms affected in these children and ultimately identify new treatment options for childhood epilepsy patients.

Conditions

Rolandic Epilepsy, Rolandic Epilepsy, Benign, Centrotemporal Epilepsy, Centrotemporal; EEG Spikes, Epilepsy of Childhood, Epilepsy; Seizure, Epilepsy

Study Overview

Study Details

Study overview

The investigators are recruiting children with Rolandic epilepsy and children without epilepsy (aged 4 years old and above) for a non-invasive brain imaging study using Magnetic Resonance Imaging (MRI), Magnetoencephalography/Electroencephalography (MEG/EEG), and experimental tasks. The investigators hope to determine the brain circuits and brain rhythms affected in these children and ultimately identify new treatment options for childhood epilepsy patients.

Auditory Stimulation Effect on Spindles and Sleep Dependent Learning in Rolandic Epilepsy

Sleep Spindles and Memory in Rolandic Epilepsy

Condition
Rolandic Epilepsy
Intervention / Treatment

-

Contacts and Locations

Charlestown

Athinoula A. Martinos Center Biomedical Imaging, Charlestown, Massachusetts, United States, 02129

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Ages 4-18 years
  • 2. Diagnosed with childhood epilepsy with centrotemporal spikes (CECTS) or Rolandic epilepsy by child neurologist
  • 3. Has EEG with sleep activated centrotemporal spikes
  • 4. Has had at least 1 focal motor or generalized seizure
  • 1. Has abnormal brain MRI
  • 2. Has other unrelated neurological disease
  • 3. Unable to have an MRI/MEG
  • 1. Claustrophobic
  • 2. History of frequent vomiting
  • 3. Permanent metal in body, braces
  • 4. Over MRI weight limit: 350lbs

Ages Eligible for Study

4 Years to 18 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Massachusetts General Hospital,

Catherine Chu, MD, PRINCIPAL_INVESTIGATOR, Massachusetts General Hospital

Study Record Dates

2025-12-31