Choosing Ovarian Preservation or Removal Before Surgery for Endometrial Cancer

Description

The purpose of this study is to learn more about the factors that influence decision-making before surgery (distress about cancer and/or reproductive concerns) and the possibility of regret after surgery.

Conditions

Endometrial Cancer

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Study Overview

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Study Details

Study overview

The purpose of this study is to learn more about the factors that influence decision-making before surgery (distress about cancer and/or reproductive concerns) and the possibility of regret after surgery.

Preservation of Ovaries in Endometrial Malignancies: GYN POEM Trial

Choosing Ovarian Preservation or Removal Before Surgery for Endometrial Cancer

Condition
Endometrial Cancer
Intervention / Treatment

-

Contacts and Locations

Hartford

Hartford Healthcare (Data Collection), Hartford, Connecticut, United States, 06102

Basking Ridge

Memorial Sloan Kettering Basking Ridge (All Protocol Activities), Basking Ridge, New Jersey, United States, 07920

Middletown

Memorial Sloan Kettering Monmouth (All protocol activities), Middletown, New Jersey, United States, 07748

Montvale

Memorial Sloan Kettering Bergen (All protocol activities), Montvale, New Jersey, United States, 07645

Commack

Memorial Sloan Kettering Cancer Center @ Suffolk (All protocol activities), Commack, New York, United States, 11725

Harrison

Memorial Sloan Kettering Westchester (All protocol activities), Harrison, New York, United States, 10604

New York

Memorial Sloan Kettering Cancer Center (All Study Activities), New York, New York, United States, 10065

Rockville Centre

Memorial Sloan Kettering Nassau (All protocol activities), Rockville Centre, New York, United States, 11553

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Women aged ≥ 18 and ≤ 50 years
  • * Premenopausal
  • * Endometrioid histological diagnosis
  • * Scheduled for surgical intervention at MSKCC
  • * FIGO grade 1-2, clinical stage I
  • * Disease confined to uterus, no clear evidence of deep (≥50%) myoinvasion on imaging (MRI preferred, ultrasound optional)
  • * Normal ovaries on preoperative imaging
  • * Able to provide informed consent
  • * English-speaking
  • * Known Lynch syndrome
  • * Prior bilateral oophorectomy
  • * Personal history of hormone receptor-positive breast carcinoma
  • * Increased risk of ovarian cancer identified on the basis of family or personal history
  • * Women currently on hormonal contraception, letrozole, or tamoxifen may not opt-in to AMH
  • * Women who recently underwent ovarian stimulation within the past 3 months may not opt-in to AMH
  • * Women who have pituitary dysfunction (or any pituitary disorders) may not opt-in to AMH
  • * Women who completed chemotherapy within \<12 months may not opt-in to AMH

Ages Eligible for Study

18 Years to 50 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Memorial Sloan Kettering Cancer Center,

Jennifer Mueller, MD, PRINCIPAL_INVESTIGATOR, Memorial Sloan Kettering Cancer Center

Study Record Dates

2024-09-23