RECRUITING

Effects of Blocking Blue Light at Night Post CABG, AVR, MVR, CABG AVR, CABG MVR, or SAH

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Purpose The purpose of this study is to determine whether filtering out blue light at nighttime reduces post-surgical inflammation and/or moderates cognitive decline and mood and sleep alterations in patients undergoing elective CABG, AVR, MVR, CABG AVR, CABG MVR, or SAH surgery. If manipulating nighttime light in hospital rooms improves patient outcomes, then it would be a relatively easy and inexpensive innovation that could reduce post-surgical complications and save millions of dollars per year in health care costs by shortening the length of hospital stays and reducing morbidity. The investigators aim to determine the relationship between inflammation and cognitive dysfunction after cardiac surgery.

Official Title

Effects of Blocking Blue Light at Night on Patient Outcomes After Elective CABG, AVR, MVR, CABG AVR, CABG MVR, or SAH

Quick Facts

Study Start:2021-09-20
Study Completion:2025-03
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04578249

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:45 Years to 75 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Both men and women that are undergoing elective (non-emergency)
  2. * on-pump CABG surgery,
  3. * AVR,
  4. * MVR,
  5. * CABG AVR,
  6. * CABG MVR or
  7. * SAH
  8. * No history of diagnosed psychiatric disorders or organ failure
  1. * Evidence or diagnosis of dementia or other cognitive deficit
  2. * Diagnosed psychiatric disorder (including depression and anxiety)
  3. * Organ failure \[kidney (creatine \> 1.5 mg/dL), liver, etc.\]
  4. * Chronic obstructive pulmonary disease,
  5. * Any immune disorder
  6. * Acute infection
  7. * Prior cardiac surgery
  8. * Elective aneurysms
  9. * Combined cardiac operations
  10. * Left main stenosis greater than 70%
  11. * Left ventricular ejection fraction (LVEF) lower than 0.5
  12. * Any condition that increases likelihood of the need for a blood transfusion during or after the surgery
  13. * Clotting disorder
  14. * Suspected less than 8th grade English reading comprehension level

Contacts and Locations

Study Contact

James C Walton, PhD
CONTACT
3042933490
james.walton@hsc.wvu.edu
Olga H Meléndez-Fernández, BS
CONTACT
3042930272
ohm0001@mix.wvu.edu

Principal Investigator

Randy J Nelson, PhD
PRINCIPAL_INVESTIGATOR
West Virginia University

Study Locations (Sites)

West Virginia University Heart and Vascular Institute
Morgantown, West Virginia, 26506
United States

Collaborators and Investigators

Sponsor: West Virginia University

  • Randy J Nelson, PhD, PRINCIPAL_INVESTIGATOR, West Virginia University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-09-20
Study Completion Date2025-03

Study Record Updates

Study Start Date2021-09-20
Study Completion Date2025-03

Terms related to this study

Keywords Provided by Researchers

  • CABG
  • coronary artery bypass graft
  • light at night
  • dim light at night
  • inflammation
  • cognition
  • blue light

Additional Relevant MeSH Terms

  • Circadian Rhythm Disorders