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Effects of Obesity and Intensity of Exercise on Ghrelin Levels

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Conditions

ObesityInsulin ResistanceCardiovascular Risk Factorexerciseghrelinvascular functionprediabetes

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study is investigating the effect of different intensities of exercise on levels of the hormone, ghrelin. In addition, we will be examining the relationship between any exercise induced changes in ghrelin and insulin sensitivity, obesity, and vascular function.

Official Title

Modulation of Ghrelin Release by Exercise Intensity: The Role of Obesity and Prediabetes Status

Quick Facts

Study Start:2020-10-14
Study Completion:2025-04-16
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT04581980

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 55 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * 18-55 years of age
  2. * BMI between 18-40 kg/m2
  3. * Untrained (reports less than 2 days/week of exercise)
  4. * Weight stable (no significant loss/gain of more than 3kg in the past 3 months)
  5. * Females must be premenopausal and report normal menstrual cycles
  1. * History of diabetes, gastrointestinal disease, or endocrine disorder
  2. * Smoking (must have quit at least 6 months prior)
  3. * Disordered eating
  4. * Females currently pregnant or undergoing fertility treatments
  5. * The following medications (due to their effect on insulin sensitivity ,endothelial function and/or ghrelin secretion): Synthetic growth hormone, metformin, synthetic insulin, sulfonylureas, meglitinides, Thiazolidinediones, DPP-4 inhibitors, GLP-1 receptor agonists, SGLT2 inhibitors , biguanides, alpha-glucosidase inhibitors, phosphodiesterase inhibitors, beta-blockers, alpha-blockers, ACE-inhibitors, ARB's, fibrates, glucocorticoids, olanzapine

Contacts and Locations

Study Locations (Sites)

University of Virginia
Charlottesville, Virginia, 22902
United States

Collaborators and Investigators

Sponsor: University of Virginia

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-10-14
Study Completion Date2025-04-16

Study Record Updates

Study Start Date2020-10-14
Study Completion Date2025-04-16

Terms related to this study

Keywords Provided by Researchers

  • exercise
  • ghrelin
  • insulin resistance
  • vascular function
  • obesity
  • prediabetes

Additional Relevant MeSH Terms

  • Obesity
  • Insulin Resistance
  • Cardiovascular Risk Factor