Effects of Obesity and Intensity of Exercise on Ghrelin Levels

Description

This study is investigating the effect of different intensities of exercise on levels of the hormone, ghrelin. In addition, we will be examining the relationship between any exercise induced changes in ghrelin and insulin sensitivity, obesity, and vascular function.

Conditions

Obesity, Insulin Resistance, Cardiovascular Risk Factor

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Study Overview

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Study Details

Study overview

This study is investigating the effect of different intensities of exercise on levels of the hormone, ghrelin. In addition, we will be examining the relationship between any exercise induced changes in ghrelin and insulin sensitivity, obesity, and vascular function.

Modulation of Ghrelin Release by Exercise Intensity: The Role of Obesity and Prediabetes Status

Effects of Obesity and Intensity of Exercise on Ghrelin Levels

Condition
Obesity
Intervention / Treatment

-

Contacts and Locations

Charlottesville

University of Virginia, Charlottesville, Virginia, United States, 22902

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 18-55 years of age
  • * BMI between 18-40 kg/m2
  • * Untrained (reports less than 2 days/week of exercise)
  • * Weight stable (no significant loss/gain of more than 3kg in the past 3 months)
  • * Females must be premenopausal and report normal menstrual cycles
  • * History of diabetes, gastrointestinal disease, or endocrine disorder
  • * Smoking (must have quit at least 6 months prior)
  • * Disordered eating
  • * Females currently pregnant or undergoing fertility treatments
  • * The following medications (due to their effect on insulin sensitivity ,endothelial function and/or ghrelin secretion): Synthetic growth hormone, metformin, synthetic insulin, sulfonylureas, meglitinides, Thiazolidinediones, DPP-4 inhibitors, GLP-1 receptor agonists, SGLT2 inhibitors , biguanides, alpha-glucosidase inhibitors, phosphodiesterase inhibitors, beta-blockers, alpha-blockers, ACE-inhibitors, ARB's, fibrates, glucocorticoids, olanzapine

Ages Eligible for Study

18 Years to 55 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Virginia,

Study Record Dates

2024-07