Acne is common illness of adolescents and young adults which is associated with substantial morbidity. While topical treatments are often sufficient for mild acne, moderate to severe acne often requires treatment with systemic medications such as oral antibiotics, hormonal therapies such spironolactone, and isotretinoin. Sebum overproduction is fundamental to the pathogenesis of acne with associated disordered keratinization and subsequent microbial colonization and inflammation resulting in the clinical manifestations of acne. Given the influence of hormones on sebum production, therapies that address these underlying hormonal factors such as spironolactone and oral contraceptive pills represent an underutilized treatment option for women with acne and could help decrease the use of long-term oral antibiotics in this patient population. The purpose of this trial is to evaluate the comparative effectiveness of spironolactone versus doxycycline hyclate (tetracycline class antibiotic) for women with acne.
Acne
Acne is common illness of adolescents and young adults which is associated with substantial morbidity. While topical treatments are often sufficient for mild acne, moderate to severe acne often requires treatment with systemic medications such as oral antibiotics, hormonal therapies such spironolactone, and isotretinoin. Sebum overproduction is fundamental to the pathogenesis of acne with associated disordered keratinization and subsequent microbial colonization and inflammation resulting in the clinical manifestations of acne. Given the influence of hormones on sebum production, therapies that address these underlying hormonal factors such as spironolactone and oral contraceptive pills represent an underutilized treatment option for women with acne and could help decrease the use of long-term oral antibiotics in this patient population. The purpose of this trial is to evaluate the comparative effectiveness of spironolactone versus doxycycline hyclate (tetracycline class antibiotic) for women with acne.
Comparative Effectiveness Study of Spironolactone Versus Doxycycline for Acne
-
Johnson Dermatology, Fort Smith, Arkansas, United States, 72916
University of California San Francisco, San Francisco, California, United States, 94115
University of Miami, Miami, Florida, United States, 33136
New Horizon Research Center, Miami, Florida, United States, 33165
Dawes Fretzin Clinical Research Group, Indianapolis, Indiana, United States, 46250
Brigham and Women's Hospital, Boston, Massachusetts, United States, 02115
Dermatologists of Central States, Cincinnati, Ohio, United States, 45242
Ohio State University Medical Center, Columbus, Ohio, United States, 43215
Oregon Health and Science University, Portland, Oregon, United States, 97239
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States, 19104
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
16 Years to 40 Years
FEMALE
Yes
University of Pennsylvania,
2026-07-31