Poly-omic Predictors of Symptom Duration and Recovery for Adolescent Concussion

Description

The purpose of this study is to identify changes in salivary micro ribonucleic acid (miRNA) levels that are predictive of symptom duration and character following mild traumatic brain injury (mTBI) in children.

Conditions

Concussion, Mild

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Study Overview

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Study Details

Study overview

The purpose of this study is to identify changes in salivary micro ribonucleic acid (miRNA) levels that are predictive of symptom duration and character following mild traumatic brain injury (mTBI) in children.

Poly-omic Predictors of Symptom Duration and Recovery for Adolescent Concussion

Poly-omic Predictors of Symptom Duration and Recovery for Adolescent Concussion

Condition
Concussion, Mild
Intervention / Treatment

-

Contacts and Locations

Boston

Boston Children's Hosptial, Boston, Massachusetts, United States, 02115

New York

Weill Cornell Medicine/ New York Presbyterian Hospital, New York, New York, United States, 10021

Syracuse

SUNY Upstate Medical University, Syracuse, New York, United States, 13210

Cincinnati

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States, 45229

Hershey

Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States, 17033

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Presence of mTBI: defined by criteria from the Berlin Consensus Statement and WHO. Assessment for mTBI status be performed by a licensed clinician per the 2018 CDC guidelines.
  • * Age at enrollment: 13-18 years of age (inclusive).
  • * \> 48 hours after initial mTBI
  • * Glasgow Coma Scale score of 13 or less
  • * Previous moderate-to-severe TBI requiring overnight hospitalization
  • * Unresolved symptoms from previous concussion, or any concussion within the last 3 months
  • * Abbreviated Injury Scale (AIS) score \> 3 (to reduce confounding from poly-trauma)
  • * Psychiatric illness requiring previous hospitalization;
  • * Neurological condition (e.g. epilepsy, hydrocephalus) or abnormality on neuroimaging (if performed)
  • * Intellectual disability that prevents ability to provide informed assent
  • * Pregnancy
  • * Active substance use/dependence
  • * Previous neurosurgery
  • * Non-fluency in English
  • * Upper respiratory infection
  • * Periodontal infection
  • * Injury to the oropharynx
  • * Previously enrolled in the same study
  • * Inability to complete follow-up assessments

Ages Eligible for Study

13 Years to 18 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Milton S. Hershey Medical Center,

Steve Hicks, MD, PhD, PRINCIPAL_INVESTIGATOR, Penn State University, College of Medicine

Study Record Dates

2026-01