ACTIVE_NOT_RECRUITING

Cardiovascular and Neurovascular Regulation in GWI

Conditions

Brain Blood Flow Neurovascular Control MRI Sympathetic Nerve Activity Cardiorespiratory Fitness

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Brain blood flow regulation and autonomic dysfunction will be measured in Veterans with and without Gulf War Illness who served in the Gulf War between 1990 and 1992.

Official Title

Autonomic Dysfunction, Brain Blood Flow and Cognitive Decline in Veterans With Gulf War Illness

Quick Facts

Study Start:2023-05-16

Study Completion:2025-07

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:ACTIVE_NOT_RECRUITING

Study ID

NCT04586049

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:45 Years to 68 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Deployed to the Persian Gulf between 1990-1992 * Body mass \<300 lbs * Diagnosis of Gulf War Illness based on CMI/CDC and Kansas definitions or No diagnosis of Gulf War Illness	* Current or lifetime evidence of: Type II diabetes, neurological disease, cancer treatment, rheumatoid arthritis, lupus, bipolar disorder, psychotic disorders, or mood disorders with psychotic features * Current illicit substance use or partial remission for less than 1 year * Taking multiple sedatives or anticonvulsant medications * Currently pregnant * Absolute contraindications to exercise testing * Contraindications to MRI * Other significant medical conditions at investigator's discretion

Inclusion Criteria

Exclusion Criteria

* Deployed to the Persian Gulf between 1990-1992
* Body mass \<300 lbs
* Diagnosis of Gulf War Illness based on CMI/CDC and Kansas definitions or No diagnosis of Gulf War Illness

* Current or lifetime evidence of: Type II diabetes, neurological disease, cancer treatment, rheumatoid arthritis, lupus, bipolar disorder, psychotic disorders, or mood disorders with psychotic features
* Current illicit substance use or partial remission for less than 1 year
* Taking multiple sedatives or anticonvulsant medications
* Currently pregnant
* Absolute contraindications to exercise testing
* Contraindications to MRI
* Other significant medical conditions at investigator's discretion

Contacts and Locations

Principal Investigator

Jill N Barnes, PhD

PRINCIPAL_INVESTIGATOR

University of Wisconsin, Madison

Study Locations (Sites)

University of Wisconsin-Madison

Madison, Wisconsin, 53706

United States

Collaborators and Investigators

Sponsor: University of Wisconsin, Madison

Jill N Barnes, PhD, PRINCIPAL_INVESTIGATOR, University of Wisconsin, Madison

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-05-16

Study Completion Date2025-07

Study Record Updates

Study Start Date2023-05-16

Study Completion Date2025-07

Terms related to this study

Keywords Provided by Researchers

MRI
Brain Blood Flow
Sympathetic Nerve Activity
Cardiorespiratory Fitness

Additional Relevant MeSH Terms

Brain Blood Flow
Neurovascular Control