Researching the Effect of Exercise on Cancer

Description

Researchers think that exercise may be able to prevent cancer from coming back by lowering ctDNA levels. The purpose of this study is to explore how aerobic exercise (exercise that stimulates and strengthens the heart and lungs and improves the body's use of oxygen) can reduce the level of ctDNA found in the blood. During the study, the highest level of exercise that is practical, is safe, and has positive effects on the body that may prevent the return of cancer (including a decrease in ctDNA levels) will be found. Each level of exercise tested will be a certain number of minutes each week. Once the best level of exercise is found, it will be tested further in a new group of participants. All participants in this study will have been previously treated for breast, prostate, or colorectal cancer.

Conditions

Breast Cancer, Prostate Cancer, Colorectal Cancer, Stage I Breast Cancer, Stage II Breast Cancer, Stage III Breast Cancer, Stage I Prostate Cancer, Stage II Prostate Cancer, Stage III Prostate Cancer, Stage I Colorectal Cancer, Stage II Colorectal Cancer, Stage III Colorectal Cancer

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Study Overview

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Study Details

Study overview

Researchers think that exercise may be able to prevent cancer from coming back by lowering ctDNA levels. The purpose of this study is to explore how aerobic exercise (exercise that stimulates and strengthens the heart and lungs and improves the body's use of oxygen) can reduce the level of ctDNA found in the blood. During the study, the highest level of exercise that is practical, is safe, and has positive effects on the body that may prevent the return of cancer (including a decrease in ctDNA levels) will be found. Each level of exercise tested will be a certain number of minutes each week. Once the best level of exercise is found, it will be tested further in a new group of participants. All participants in this study will have been previously treated for breast, prostate, or colorectal cancer.

Phase 1a/b Trial of Exercise as Interception Therapy for Primary High-Risk Cancer

Researching the Effect of Exercise on Cancer

Condition
Breast Cancer
Intervention / Treatment

-

Contacts and Locations

San Carlos

Natera, Inc. (Data or Specimen Analysis Only), San Carlos, California, United States, 94070

Basking Ridge

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey, United States, 07920

Middletown

Memorial Sloan Kettering Monmouth (Limited Protocol Activities), Middletown, New Jersey, United States, 07748

Montvale

Memorial Sloan Kettering Bergen (Limited Protocol Activities), Montvale, New Jersey, United States, 07645

Commack

Memorial Sloan Kettering Commack (Limited Protocol Activities), Commack, New York, United States, 11725

Harrison

Memorial Sloan Kettering Westchester (Limited Protocol Activities), Harrison, New York, United States, 10604

New York

Memorial Sloan Kettering Cancer Center, New York, New York, United States, 10065

Uniondale

Memorial Sloan Kettering Nassau (Limited Protocol Activities), Uniondale, New York, United States, 11553

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Postsurgical diagnosis of patients with primary solid tumors at high-risk of relapse as defined by one of the following:
  • * Stage 3 or
  • * ctDNA positive
  • * Residual invasive disease in the breast or the lymph nodes following completion of neoadjuvant chemotherapy (NACT),
  • * Estrogen receptor (ER), and/or progesterone receptor (PR) positive and HER2 negative,
  • * CPS-EG score ≥ 3,
  • * CPS-EG score ≥2 w ith ypN+, or
  • * Recurrence score ≥ 25
  • * No evidence of disease
  • * Age ≥ 18
  • * Interval of ≥ 1 month but ≤ 2 years following completion of all definitive adjuvant therapy
  • * Non-exercising (i.e., \< 30 minutes of moderate and \< 20 mins of vigorous exercise/wk), as assessed by remote activity and heart rate tracking for a 7-day period prior to study entry)
  • * Cleared for exercise participation as per screening clearance via PAR-Q+
  • * Willingness to comply with all study-related procedures
  • * Enrollment onto any other interventional investigational study except interventions determined by the PI not to confound study outcomes
  • * Any other current diagnosis of invasive cancer of any kind
  • * Distant metastatic malignancy of any kind
  • * Any other condition or intercurrent illness that, in the opinion of the investigator, makes the subject a poor candidate for study participation

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Memorial Sloan Kettering Cancer Center,

Lee Jones, PhD, PRINCIPAL_INVESTIGATOR, Memorial Sloan Kettering Cancer Center

Study Record Dates

2025-10-02