RECRUITING

Obesity and Pediatric Multiple Sclerosis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Obesity is one possible contributor to severity of multiple sclerosis and progression of the disease. We already know that obesity is a risk determinant for acquiring MS, yet the impact of obesity on pediatric MS disease expression and course is unknown. This study will evaluate the relationship between obesity, obesity-derived inflammatory mediators, and imaging metrics of MS severity in children. Understanding how childhood obesity contributes to MS severity/progression may yield fundamental insights into disease pathobiology - which may thereby lead to effective strategies for halting its progression in its earliest stages.

Official Title

Obesity as a Driver of Inflammation and Brain Volume Loss in Pediatric Multiple Sclerosis.

Quick Facts

Study Start:2021-06-03
Study Completion:2024-09-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04593082

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:10 Years to 20 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD, ADULT
Inclusion CriteriaExclusion Criteria
  1. * Ability to provide informed consent (or assent for minors)
  2. * Relapsing-remitting MS diagnosis per 2017 McDonald criteria
  3. * Ages ≥ 10 years to ≤ 20 years
  4. * Diagnosis of MS or first clinical symptom of MS (whichever comes first) within ≤ 36 months from the time of enrollment.
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

J Nicholas Brenton, MD
CONTACT
434-982-3936
jnb8h@virginia.edu
Margaret Keller
CONTACT
434-297-4102
mfk8e@hscmail.mcc.virginia.edu

Principal Investigator

J Nicholas Brenton, MD
PRINCIPAL_INVESTIGATOR
University of Virginia

Study Locations (Sites)

Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104
United States
University of Virginia
Charlottesville, Virginia, 22903
United States

Collaborators and Investigators

Sponsor: University of Virginia

  • J Nicholas Brenton, MD, PRINCIPAL_INVESTIGATOR, University of Virginia

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-06-03
Study Completion Date2024-09-01

Study Record Updates

Study Start Date2021-06-03
Study Completion Date2024-09-01

Terms related to this study

Keywords Provided by Researchers

  • Pediatric
  • Obesity
  • Neurodegeneration
  • Inflammation

Additional Relevant MeSH Terms

  • Multiple Sclerosis