Pubertal Blockade and Estradiol Effects on Cardiometabolic Health for Transitioning Youth

Description

To evaluate the effect of estradiol with or without a prior gonadotropin releasing hormone analogue on insulin sensitivity and vascular function in transgender females compared to cisgender controls.

Conditions

Transgenderism, Gender Dysphoria, Insulin Sensitivity

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Study Overview

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Study Details

Study overview

To evaluate the effect of estradiol with or without a prior gonadotropin releasing hormone analogue on insulin sensitivity and vascular function in transgender females compared to cisgender controls.

Pubertal Blockade and Estradiol Effects on Cardiometabolic Health for Transitioning Youth

Pubertal Blockade and Estradiol Effects on Cardiometabolic Health for Transitioning Youth

Condition
Transgenderism
Intervention / Treatment

-

Contacts and Locations

Aurora

Children's Hospital Colorado, Aurora, Colorado, United States, 80045

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Cognitive, psychiatric, or physical impairment resulting in inability to tolerate the study procedures
  • * Antipsychotic medication use
  • * Type 1 or 2 diabetes (by medical history)
  • * Polycystic ovarian syndrome (PCOS for cisgender females)
  • * Hypertension (resting BP ≥ 140/90 mm/Hg)
  • * Weight\> 400 lbs
  • * On oral progesterone medications (including oral progesterone or progestin, combined oral contraceptives or etonogestrel implant)
  • * Pregnancy (for cisgender females)

Ages Eligible for Study

13 Years to 16 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Colorado, Denver,

Natalie Nokoff, MD, MSCS, PRINCIPAL_INVESTIGATOR, University of Colorado, Denver

Study Record Dates

2025-07-31